Results 71 to 80 of about 12,340 (179)

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source

Circulant Matrix‐Based Box–Behnken Designs With Economic Run Sizes

Quality and Reliability Engineering International, EarlyView.
ABSTRACT We introduce Circulant Matrix‐Based Box–Behnken Designs (CBBDs), a new class of three‐level, second‐order response surface designs constructed using circulant matrix structures. These designs satisfy an enhanced orthogonal minimally aliased (OMA∗${\rm OMA}^*$) property: they retain the classical OMA property—where main effects are orthogonal ...
Tung‐Dinh Pham, Nam‐Ky Nguyen
wiley   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

BayesianKAN: A reaction condition optimization framework integrating Kolmogorov‐Arnold network and Bayesian optimization

Smart Molecules, EarlyView.
A novel BayesianKAN framework integrates Kolmogorov‐Arnold networks with Bayesian optimization to efficiently navigate complex factor spaces, accelerating the discovery of optimal reaction conditions for chemical synthesis. Abstract Efficient optimization of chemical reaction conditions is crucial for enhancing reaction yield and selectivity, yet ...
Juntao Wang, Yujing Zhao, Peiyu Yi, Liyuan Duan, Qingwei Meng, Qilei Liu   +5 more
wiley   +1 more source

Fish Scales: A Multifunctional Biomaterial from Nature

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Dynamic, Unconstrained Optimization of Secreted Enzyme Production in Fed‐Batch Fermentation Using Reinforcement Learning

Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2024-2036, August 2026.
ABSTRACT Reinforcement learning (RL) has been used to control a wide range of dynamic processes, especially ones that are too complex to model well or have stochastic environmental perturbations. Fed‐batch fermentations are subject to changes in starting cell growth rates and process variations that can affect cell growth and secreted target production.
Sai Harish Uthravalli, Sakib Ferdous, J. Michael Hess, Nigel F. Reuel   +3 more
wiley   +1 more source

From Fish Waste to Stable Omega‐3 Bioactive Lipids: Encapsulation Strategies and a Conceptual Framework for Antioxidant and Antimicrobial Functional Food Fortification

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Fish waste is valorized into omega‐3‐rich bioactive lipids (EPA and DHA), followed by stabilization through advanced encapsulation technologies to prevent oxidation and improve storage stability. Encapsulation protects polyunsaturated fatty acids from oxidation, improves storage stability, enables controlled gastrointestinal release, and enhances ...
Abebe Desalegn, Habtamu Admassu, Gadissa Mosisa, Gebeyehu Ayele, Molla Abeje, Tanaji Kudre   +5 more
wiley   +1 more source

Development of Functional Bread Fortified with Hawthorn Leaf Phenolic Extract: Evaluation of Technological Performance and Phenolic Bioaccessibility

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study investigates the production of hawthorn (Crataegus azarolus) leaf extract–fortified functional bread. Ultrasound‐assisted extraction was optimized using Response Surface Methodology (Box–Behnken design) by adjusting extraction time, temperature, and ethanol concentration.
Semra Topuz Türker, Esra Esin, Mustafa Bayram, Cemal Kaya   +3 more
wiley   +1 more source

Optimization of Selenite Removal by Lactobacillus sp. Tra cheese 6 Using Box-Behnken Design [PDF]

Journal of Kerman University of Medical Sciences, 2016
Background & Aims: High concentrations of selenite have carcinogenetic, cytotoxic and genotoxic effects. Therefore, removal of this toxic pullutant from the environment has a particular importance in maintaining public health. In this study, with the aim
Morahem Ashengroph, Davoud Saedi
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