Results 61 to 70 of about 12,404 (179)

Design, development and optimization of gastro-retentive floating in-situ gels loaded with carvedilol microspheres using response surface methodology

Acta Marisiensis - Seria Medica
Aim: The goal of this study was to formulate and optimize gastro-retentive floating in-situ gel comprising optimized microspheres by Box-Behnken design.
Kukati Latha, Rahman Aisha, Fatima Aymen, Menon Vyshak R, Lakshmi SVVNSM   +4 more
doaj   +1 more source

Bioactive L acidissima protein hydrolysates using Box–Behnken design [PDF]

3 Biotech, 2017
This study examines the extraction and hydrolysis of proteins using single factor and Box-Behnken Design (BBD). From single factor tests, optimised extraction parameters were 1% alkali concentration, 40 °C temperature, 60 min time, and 1:20 solid to alkali ratio. Under these conditions; 924.31 mg/g of total protein was obtained from Limonia acidissima (
Sachin K, Sonawane, Shalini S, Arya
openaire   +2 more sources

Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari, Ioanna Pitterou, Marianthi Miliaronikolaki, Nikolaos Paraskevopoulos, Andromachi Tzani, Anastasia Detsi   +5 more
wiley   +1 more source

Circulant Matrix‐Based Box–Behnken Designs With Economic Run Sizes

Quality and Reliability Engineering International, EarlyView.
ABSTRACT We introduce Circulant Matrix‐Based Box–Behnken Designs (CBBDs), a new class of three‐level, second‐order response surface designs constructed using circulant matrix structures. These designs satisfy an enhanced orthogonal minimally aliased (OMA∗${\rm OMA}^*$) property: they retain the classical OMA property—where main effects are orthogonal ...
Tung‐Dinh Pham, Nam‐Ky Nguyen
wiley   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source

BayesianKAN: A reaction condition optimization framework integrating Kolmogorov‐Arnold network and Bayesian optimization

Smart Molecules, EarlyView.
A novel BayesianKAN framework integrates Kolmogorov‐Arnold networks with Bayesian optimization to efficiently navigate complex factor spaces, accelerating the discovery of optimal reaction conditions for chemical synthesis. Abstract Efficient optimization of chemical reaction conditions is crucial for enhancing reaction yield and selectivity, yet ...
Juntao Wang, Yujing Zhao, Peiyu Yi, Liyuan Duan, Qingwei Meng, Qilei Liu   +5 more
wiley   +1 more source

Fish Scales: A Multifunctional Biomaterial from Nature

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley   +1 more source

Extrusion‐Based Additive Manufacturing of Advanced Ceramics: Strengthening Mechanisms and Process Optimization Review

Advanced Engineering Materials, Volume 28, Issue 16, 19 August 2026.
This review comprehensively evaluates extrusion‐based additive manufacturing for advanced ceramics, detailing feedstock options and key process parameters. By critically addressing defect mechanisms like porosity and cracking, the work highlights optimization strategies through machine learning and advanced postprocessing.
Meisam Bakhtiari, Mohammad Hadi Sheikh‐Ansari, Avinash Borgaonkar, Mehran Dadkhah, Abdollah Saboori   +4 more
wiley   +1 more source

Cornus Mas L. Seed‐Derived Biosorbent for Methylene Blue Removal: Surface Characterization and Biosorption Performance

Advanced Materials Interfaces, Volume 13, Issue 16, 18 August 2026.
Cornus mas L. seeds are transformed into a high‐performance biosorbent through chemical modification, effectively removing methylene blue from aqueous solutions. Comprehensive characterization and optimization reveal a maximum biosorption capacity of 71.71 mg g−1, establishing this sustainable, cost‐effective material as a promising solution for ...
Hakan Yıldız, Adem Necip, Arslan Yusuf Yüksel   +2 more
wiley   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source