Results 61 to 70 of about 1,009,431 (281)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A holistic approach to determine tree structural complexity based on laser scanning data and fractal analysis

open access: yesEcology and Evolution, 2018
The three‐dimensional forest structure affects many ecosystem functions and services provided by forests. As forests are made of trees it seems reasonable to approach their structure by investigating individual tree structure.
Dominik Seidel
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Drivers of Forest Structural Complexity in Mountain Forests of Nepal

open access: yesMountain Research and Development
Forests in the Himalayan region are crucial for maintaining the region's ecological balance, conserving biodiversity, and supporting the livelihoods of local people.
Prakash Basnet   +4 more
doaj   +1 more source

Robustness of Device Independent Dimension Witnesses

open access: yes, 2012
Device independent dimension witnesses provide a lower bound on the dimensionality of classical and quantum systems in a "black box" scenario where only correlations between preparations, measurements and outcomes are considered.
Antonio Acín   +5 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Fatigue damage evolution characteristics and time effect analysis of coal rock based on CT three-dimensional reconstruction

open access: yesMeitan kexue jishu
In order to deeply explore the fatigue damage evolution characteristics of coal rock under different creep damage conditions, and reveal the internal relationship between the structural changes of complex pores and fractures in coal rock and its ...
Yangyang LI   +5 more
doaj   +1 more source

Fractal Dimension Analysis of the Julia Sets of Controlled Brusselator Model

open access: yesDiscrete Dynamics in Nature and Society, 2016
Fractal theory is a branch of nonlinear scientific research, and its research object is the irregular geometric form in nature. On account of the complexity of the fractal set, the traditional Euclidean dimension is no longer applicable and the ...
Yuqian Deng   +2 more
doaj   +1 more source

Box Dimension and Cyclicity of Canard Cycles [PDF]

open access: yesQualitative Theory of Dynamical Systems, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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