Results 171 to 180 of about 159,946 (279)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Neuromotor adaptations in people with Parkinson's Disease following a 12-month multimodal non-contact boxing intervention. [PDF]

Front Hum Neurosci
King AC, Carr JC, Voskuil C, Chen K, Porter RR, Thijs Z, Watts CR.   +6 more
europepmc   +1 more source

Little boxes [PDF]

Nature Genetics, 2014
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sport performance in virtual worlds: a systematic review of sport simulation in neurological paralympic athletes and non-athlete populations. [PDF]

BMC Sports Sci Med Rehabil
Calabrò RS, Calderone A, Maggio MG, Speciale F, Bruschetta D, Lanza M, Quartarone A.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hyper-selective explainability: an empirical case study of the utility of explainability in a clinical decision support system. [PDF]

AI Ethics
Duke SA, Sandøe P, Lund TB, Abenavoli EM, Beyer T, Ferrara D, Frille A, Gruenert S, Sabri O, Sciagrà R, Pepponi M, Swen H, Tönjes A, Wirtz H, Yu J, Shiyam Sundar LK, Holm S.   +16 more
europepmc   +1 more source

Pandora's Box

BJPsych International, 2022
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Demodicosis Mite Detection in Eyes with Blepharitis and Meibomian Gland Dysfunction Based on Deep Learning Model. [PDF]

Diagnostics (Basel)
Mai EL, Tseng YL, Lee HT, Sun WH, Tsai HH, Chien TY.   +5 more
europepmc   +1 more source