Results 11 to 20 of about 46,751 (115)

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. [PDF]

Protein Sci
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Chatziefthymiou SD, Kuzikov M, Afandi S, Kovacs G, Srivastava S, Zaliani A, Gruzinov A, Pompidor G, Lunelli M, Ahmed GR, Labahn J, Hakanpää J, Windshügel B, Kolbe M.   +13 more
europepmc   +2 more sources

A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation. [PDF]

J Arrhythm
This cross‐tissue transcriptome‐wide association study identified five novel AF susceptibility genes (CAMK2D, SPAST2L, CEP68, FKBP7, and SHRMOO3). Elevated expression of FKBP7, CEP68, and CAMK2D increases AF risk, while SPATS2L shows a protective effect, with colocalization analysis implicating CEP68 and SPATS2L as prioritized candidates.
Yuan Y, Zheng X, Zhang W, Ren Z, Liang B.   +4 more
europepmc   +2 more sources

Short-Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study. [PDF]

Aging Cell
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Cagigas ML, Masedunskas A, Lin Y, Emery-Corbin SJ, Yousef JM, Dagley LF, Olechnowicz S, Bowden R, Hayward R, Low G, Muirhead R, Brand-Miller J, Fogeltholm M, Raben A, Demaria M, Fuller SJ, Fontana L.   +16 more
europepmc   +2 more sources

The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury. [PDF]

Adv Virol
Injury from spike protein, whether induced by COVID‐19 infection or vaccination, constitutes a significant health concern for numerous individuals. Considerable heterogeneity exists in individual responses to both COVID‐19 infection and vaccination, despite the latter being principally more controlled and consistent than the wide variety of infection ...
Halma M, Vottero P, Thorp J, Peers T, Tuszynski J, Marik P.   +5 more
europepmc   +2 more sources

Deubiquitylating Enzymes in Cancer and Immunity

Advanced Science, Volume 10, Issue 36, December 27, 2023., 2023
This review presents the fundamental understanding of deubiquitinating enzymes (DUBs) and then outlines the mechanisms and multi‐role of DUBs in determining the occurrence and development of tumor and immune disorders. DUBs in the crosstalk between cancer and immune response is then presented.
Jiang Ren, Peng Yu, Sijia Liu, Ran Li, Xin Niu, Yan Chen, Zhenyu Zhang, Fangfang Zhou, Long Zhang   +8 more
wiley   +1 more source

Posmodernisme: Dampak dan Penerapannya pada Studi Islam

Analisis, 2019
This paper concentrates on dialogue with postmodernism and religion while looking at some of the core ideas of postmodernism and the possibility of making it a reading tool for Islam, precisely for the benefit of Islamic studies, in contemporary society ...
Abdul Mukti Ro'uf
doaj   +1 more source

CURRENT DEBATES IN THE POSTSOEHARTO INDONESIAN ISLAM: Examining the Intellectual Base of Liberal and Anti-liberal Islamic Movement

Al-Jami'ah: Journal of Islamic Studies, 2007
This article discusses intensively the current debate between those who support and against liberalism within pluralized Indonesian Muslims.  The two groups are represented by JIL (Jaringan Islam Liberal) and MD (Media Dakwah).
Akh. Muzakki
doaj   +1 more source

Global Economic Terrorism, Forms and Their Impacts

Al-Tahrir, 2018
: Terrorism is not only a matter of security and fear but terrorism is linked to national and global economies that have economic and social impacts. Economics and terrorism have interactional relationships. A role played by large capital owners composed
Meirison Meirison
doaj   +1 more source

KHABARUL WAHID DALAM PANDANGAN ASY-SYAFI'I DALAM KITAB AR-RISALAH

Jurnal Living Hadis, 2019
Pada akhir abad kedua hijriah, ketika dunia Islam diramaikan dengan golongan yang menolak sunnah, baik keseluruhan ataupun yang wahid saja, Imam Syafi’i tampil sebagai seorang yang membela dan mempertahankan khabar al-wahid.
Sholahuddin Zamzabela, Indal Abror
doaj   +1 more source

KESALAHAN FONOLOGIS DALAM BERBICARA BAHASA ARAB PADA MAHASISWA MATRIKULASI STAIN KENDARI

Al-Izzah, 2015
Penelitian ini mengkaji tentang kesalahan fonologis dalam berbicara bahasa Arab pada mahasiswa matrikulasi STAIN Kendari. Adapun tujuan penelitian ini adalah untuk mengetahui: 1) Kesalahan fonologis dalam berbicara bahasa Arab pada mahasiswa Matrikulasi ...
Batmang Batmang
doaj   +1 more source