Results 11 to 20 of about 63,165 (118)

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. [PDF]

Protein Sci
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Chatziefthymiou SD, Kuzikov M, Afandi S, Kovacs G, Srivastava S, Zaliani A, Gruzinov A, Pompidor G, Lunelli M, Ahmed GR, Labahn J, Hakanpää J, Windshügel B, Kolbe M.   +13 more
europepmc   +2 more sources

A cross-tissue transcriptome-wide association study identifies novel susceptibility genes for atrial fibrillation. [PDF]

J Arrhythm
This cross‐tissue transcriptome‐wide association study identified five novel AF susceptibility genes (CAMK2D, SPAST2L, CEP68, FKBP7, and SHRMOO3). Elevated expression of FKBP7, CEP68, and CAMK2D increases AF risk, while SPATS2L shows a protective effect, with colocalization analysis implicating CEP68 and SPATS2L as prioritized candidates.
Yuan Y, Zheng X, Zhang W, Ren Z, Liang B.   +4 more
europepmc   +2 more sources

Short-Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study. [PDF]

Aging Cell
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Cagigas ML, Masedunskas A, Lin Y, Emery-Corbin SJ, Yousef JM, Dagley LF, Olechnowicz S, Bowden R, Hayward R, Low G, Muirhead R, Brand-Miller J, Fogeltholm M, Raben A, Demaria M, Fuller SJ, Fontana L.   +16 more
europepmc   +2 more sources

The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury. [PDF]

Adv Virol
Injury from spike protein, whether induced by COVID‐19 infection or vaccination, constitutes a significant health concern for numerous individuals. Considerable heterogeneity exists in individual responses to both COVID‐19 infection and vaccination, despite the latter being principally more controlled and consistent than the wide variety of infection ...
Halma M, Vottero P, Thorp J, Peers T, Tuszynski J, Marik P.   +5 more
europepmc   +2 more sources

Deubiquitylating Enzymes in Cancer and Immunity

Advanced Science, Volume 10, Issue 36, December 27, 2023., 2023
This review presents the fundamental understanding of deubiquitinating enzymes (DUBs) and then outlines the mechanisms and multi‐role of DUBs in determining the occurrence and development of tumor and immune disorders. DUBs in the crosstalk between cancer and immune response is then presented.
Jiang Ren, Peng Yu, Sijia Liu, Ran Li, Xin Niu, Yan Chen, Zhenyu Zhang, Fangfang Zhou, Long Zhang   +8 more
wiley   +1 more source

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Nature Communications, 2019
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR
Hannah V. Woodcock, J. Eley, D. Guillotin, M. Platé, C. Nanthakumar, Matteo Martufi, Simon Peace, G. Joberty, Daniel Poeckel, R. Good, Adam R. Taylor, N. Zinn, Matthew Redding, E. Forty, R. Hynds, C. Swanton, M. Karsdal, T. Maher, Andrew Fisher, G. Bergamini, R. Marshall, A. Blanchard, P. Mercer, R. Chambers   +23 more
semanticscholar   +1 more source

Association of congenital cardiovascular malformation and neuropsychiatric phenotypes with 15q11.2 (BP1–BP2) deletion in the UK Biobank

European Journal of Human Genetics, 2020
Deletion of a non-imprinted 500kb genomic region at chromosome 15q11.2, between breakpoints 1 and 2 of the Prader–Willi/Angelman locus (BP1–BP2 deletion), has been associated in previous studies with phenotypes including congenital cardiovascular ...
S. Williams, Apostol Nakev, Hui Guo, Simon Frain, Gennadiy Tenin, Anna Liakhovitskaia, Priyanka Saha, J. Priest, Kathryn E. Hentges, B. Keavney   +9 more
semanticscholar   +1 more source

Should We Report 15q11.2 BP1-BP2 Deletions and Duplications in the Prenatal Setting?

Journal of Clinical Medicine, 2020
Copy number variations of the 15q11.2 region at breakpoints 1-2 (BP1-BP2) have been associated with variable phenotypes and low penetrance. Detection of such variations in the prenatal setting can result in significant parental anxiety.
I. Maya, S. Perlman, M. Shohat, S. Kahana, S. Yacobson, T. Tenne, Ifaat Agmon-Fishman, Reut Tomashov Matar, L. Basel-Salmon, R. Sukenik-Halevy   +9 more
semanticscholar   +1 more source

4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response

Journal of Neuroscience, 2020
Decline of protein quality control in neurons contributes to age-related neurodegenerative disorders caused by misfolded proteins. 4E-BP1 is a key node in the regulation of protein synthesis, as activated 4E-BP1 represses global protein translation ...
S. Dastidar, M. T. Pham, M. B. Mitchell, Steven G Yeom, Sarah Jordan, Angela Chang, B. Sopher, A. L. La Spada   +7 more
semanticscholar   +1 more source

Treatment-resistant psychotic symptoms and the 15q11.2 BP1–BP2 (Burnside-Butler) deletion syndrome: case report and review of the literature

Translational Psychiatry, 2020
The 15q11.2 BP1-BP2 (Burnside-Butler) deletion is a rare copy number variant impacting four genes ( NIPA1, NIPA2, CYFIP1, and TUBGCP5 ), and carries increased risks for developmental delay, intellectual disability, and neuropsychiatric disorders ...
M. Farrell, M. Lichtenstein, M. Harner, J. Crowley, Dawn M. Filmyer, G. Lázaro-Muñoz, T. Dietterich, L. Bruno, R. Shaughnessy, Tamara F. Biondi, Stephan Burkholder, Jane Donmoyer, J. Berg, J. Szatkiewicz, P. Sullivan, R. Josiassen   +15 more
semanticscholar   +1 more source