Results 1 to 10 of about 49,552 (162)
Prader–Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review
International Journal of Molecular Sciences, 2023 Prader–Willi syndrome (PWS) is a complex genetic disorder with three PWS molecular genetic classes and presents as severe hypotonia, failure to thrive, hypogonadism/hypogenitalism and developmental delay during infancy. Hyperphagia, obesity, learning and
M. Butler
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SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1
Journal of Biological Chemistry, 2023 Breast cancer stem cells are mainly responsible for poor prognosis, especially in triple-negative breast cancer (TNBC). In a previous study, we demonstrated that ε-Sarcoglycan (SGCE), a type Ⅰ single-transmembrane protein, is a potential oncogene that ...
Ting Qiu +9 more
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The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.
Molecules and Cells, 2021 The activation of cap-dependent translation in eukaryotes requires multisite, hierarchical phosphorylation of 4E-BP by the 1 MDa kinase mammalian target of rapamycin complex 1 (mTORC1). To resolve the mechanism of this hierarchical phosphorylation at the
R. Böhm +5 more
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4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis
Protein & Cell, 2022 Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown.
Yifang He +12 more
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Fusarium BP1 is a reader of H3K27 methylation
Nucleic Acids Research, 2021 Histone H3 lysine 27 methylation catalyzed by polycomb repressive complex 2 (PRC2) is conserved from fungi to humans and represses gene transcription. However, the mechanism for recognition of methylated H3K27 remains unclear, especially in fungi.
G. Tang +13 more
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BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1
FEBS Open Bio, 2021 More than 40 000 patients worldwide die from esophageal cancer annually. The 5‐year survival rate of patients is only ~ 15–20%, and thus, there is an ongoing need to improve diagnosis and treatment of esophageal cancer.
Fengyun Wang +3 more
semanticscholar +1 more source
Nature Communications, 2021 Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis.
J. M. Githaka +12 more
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TELAAH PEMIKIRAN HADIS MAHMUD ABU RAYYAH DALAM BUKU “AḌWA’ ‘ALA AL-SUNNAH AL-MUHAMMADIYAH”
Hunafa: Jurnal Studia Islamika, 2012 : In the development of contemporary hadith studies, especially after the time of Muhammad Abduh, a number of figures who appear to have a critical view of the classical era of hadith studies. Some people rate them as al-Sunnah inkār modern.
Sochimin Sochimin
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JAMA psychiatry, 2020 Importance Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders.
D. van der Meer +131 more
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MENGEMBANGKAN PERILAKU SEHAT MELALUI PENDEKATAN SOCIAL LEARNING THEORY
Hunafa: Jurnal Studia Islamika, 2007 Prior to 1990s, the major cause of death is a cute disorder such as tuberculosis, small fox, leprosy and various infections convinced to be brought about by viruses and bacteria.
Fatimah Saguni
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