Results 1 to 10 of about 36,655 (113)

ANGPTL4 Induces TMZ Resistance of Glioblastoma by Promoting Cancer Stemness Enrichment via the EGFR/AKT/4E-BP1 Cascade

International Journal of Molecular Sciences, 2019
Glioblastoma (GBM) is the most aggressive type of brain tumor, with strong invasiveness and a high tolerance to chemotherapy. Despite the current standard treatment combining temozolomide (TMZ) and radiotherapy, glioblastoma can be incurable due to drug ...
Y. Tsai, An-Chih Wu, Wen-Bin Yang, T. Kao, J. Chuang, Wen-Chang Chang, T. Hsu   +6 more
semanticscholar   +1 more source

Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis

International Journal of Nanomedicine, 2021
Background Exosomes secreted by peritoneal macrophages (pMφ) are deeply involved in the development of endometriosis (EMs). Exosomes can mediate cell-to-cell communication by transferring biological molecules.
Ting Liu, Mei Liu, Caihua Zheng, Daoyan Zhang, Mingbao Li, Lu Zhang   +5 more
semanticscholar   +1 more source

eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.

JCI Insight, 2019
Pancreatic ductal adenocarcinoma (PDAC) relies on hyperactivated protein synthesis. Consistently, human and mouse PDAC lose expression of the translational repressor and mTOR target 4E-BP1.
D. Müller, Sauyeun Shin, T. Goullet de Rugy, R. Samain, R. Baer, Manon Strehaiano, Laia Masvidal-Sanz, J. Guillermet‐Guibert, C. Jean, Yoshinori Tsukumo, N. Sonenberg, Frédéric Marion, N. Guilbaud, J. Hoffmann, O. Larsson, C. Bousquet, S. Pyronnet, Y. Martineau   +17 more
semanticscholar   +1 more source

Estimating the effect size of the 15Q11.2 BP1–BP2 deletion and its contribution to neurodevelopmental symptoms: recommendations for practice

Journal of Medical Genetics, 2019
Background The 15q11.2 deletion is frequently identified in the neurodevelopmental clinic. Case–control studies have associated the 15q11.2 deletion with neurodevelopmental disorders, and clinical case series have attempted to delineate a microdeletion ...
A. Jønch, E. Douard, C. Moreau, Anke Van Dijck, M. Passeggeri, F. Kooy, J. Puechberty, Carolyn Campbell, D. Sanlaville, Henrietta Lefroy, S. Richetin, A. Pain, D. Geneviève, U. Kini, C. Le Caignec, J. Lespinasse, A. Skytte, B. Isidor, C. Zweier, J. Caberg, M. Delrue, R. Møller, A. Bojesen, H. Hjalgrim, C. Brasch-Andersen, E. Lemyre, L. Ousager, S. Jacquemont   +27 more
semanticscholar   +1 more source

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1–dependent mitochondrial dysfunction in the retina

Journal of Biological Chemistry, 2019
Diabetes promotes the posttranslational modification of proteins by O-linked addition of GlcNAc (O-GlcNAcylation) to Ser/Thr residues of proteins and thereby contributes to diabetic complications.
Sadie K. Dierschke, William P. Miller, John S. Favate, Premal Shah, Y. Imamura Kawasawa, Anna C. Salzberg, S. Kimball, L. Jefferson, Michael D. Dennis   +8 more
semanticscholar   +1 more source

Caffeine Potentiates Ethanol-Induced Neurotoxicity Through mTOR/p70S6K/4E-BP1 Inhibition in SH-SY5Y Cells

International journal of toxicology, 2020
Caffeine is a popular psychostimulant, which is frequently consumed with ethanol. However, the effects of caffeine on neuronal cells constantly exposed to ethanol have not been investigated.
Pongsak Sangaunchom, P. Dharmasaroja
semanticscholar   +1 more source

Parent-of-Origin Effects in 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome

International Journal of Molecular Sciences, 2019
To identify whether parent-of-origin effects (POE) of the 15q11.2 BP1-BP2 microdeletion are associated with differences in clinical features in individuals inheriting the deletion, we collected 71 individuals reported with phenotypic data and known ...
K. W. Davis, Moises A. Serrano, S. Loddo, Catherine Robinson, V. Alesi, B. Dallapiccola, A. Novelli, M. Butler   +7 more
semanticscholar   +1 more source

Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E)

Journal of Biological Chemistry, 2019
Eukaryotic translation initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) inhibits cap-dependent translation in eukaryotes by competing with eIF4G for an interaction with eIF4E.
Rui Sun, Erdong Cheng, C. Velásquez, Yuan Chang, P. Moore   +4 more
semanticscholar   +1 more source

Translational repression of Ccl5 and Cxcl10 by 4E‐BP1 and 4E‐BP2 restrains the ability of mouse macrophages to induce migration of activated T cells

European Journal of Immunology, 2019
Signaling through the mechanistic target of rapamycin complex 1 (mTORC1) is a major regulatory node of pro‐inflammatory mediator production by macrophages (MΦs).
M. William, L. Leroux, Visnu Chaparro, T. Graber, T. Alain, M. Jaramillo   +5 more
semanticscholar   +1 more source

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, 2019
Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets in the ...
O. Le Bacquer, Kristell Combe, V. Patrac, B. Ingram, L. Combaret, D. Dardevet, C. Montaurier, J. Salles, C. Giraudet, C. Guillet, N. Sonenberg, Y. Boirie, S. Walrand   +12 more
semanticscholar   +1 more source