Results 11 to 20 of about 68,758 (176)

A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties. [PDF]

Small Sci
Peroxidase is a heme‐containing enzyme that has been broadly used in medical diagnosis, environmental treatments, and chemical syntheses. Its main limitation is low expression yields and poor stability in harsh environments. Herein, the feasibility and the use of Stable protein 1, a thermo‐stable and stress‐responsive protein, conjugated with hemin as ...
Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O.   +4 more
europepmc   +2 more sources

Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. [PDF]

FEBS Open Bio
Hepatocytes can switch their metabolic processes in response to nutrient availability. We visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose‐deprivation. Glucose administration to hepatocytes under glucose deprivation conditions can cause an immediate decrease in the mitochondrial ATP concentration. In contrast,
Tsuno S, Harada K, Horikoshi M, Mita M, Kitaguchi T, Hirai MY, Matsumoto M, Tsuboi T.   +7 more
europepmc   +2 more sources

Reinforcer value moderates response magnitude and persistence during extinction: A randomized trial. [PDF]

J Appl Behav Anal
Abstract Extinction bursts, or temporary increases in rates and intensities of behavior during extinction, can preclude the inclusion of extinction in intervention packages meant to suppress severe challenging behavior. To identify underlying behavioral mechanisms responsible for response persistence and bursting, 69 adults with developmental ...
Lambert JM, Osina MA, Copeland BA.
europepmc   +2 more sources

Control of contact-inhibition by 4E-BP1 upregulation.

, 2010
International audienceAlthough contact inhibition is a fundamental process for multicellular organisms, how proliferation is inhibited at high cellular densities remains poorly characterized. Here we show that 4E-BP1, one major repressor of cap-dependent
Bousquet, Corinne, Corinne Bousquet, Christiane Susini, Azar, Rania, Susini, Christiane, Stéphane Pyronnet, Pyronnet, Stéphane, Rania Azar   +7 more
core   +4 more sources

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [PDF]

, 2009
The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation.
Kanako Kuwasako, Naohiro Kobayashi, Shirouzu, Mikako, Mari Takahashi, Yutaka Muto, Takahashi, Mari, Someya, Tatsuhiko, Takanori Kigawa, Kengo Tsuda, Kuwasako, Kanako, Kobayashi, Naohiro, Peter Güntert, Mikako Shirouzu, Muto, Yutaka, Sugano, Sumio, Akiko Tanaka, Tatsuhiko Someya, Makoto Inoue, Sumio Sugano, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Yokoyama, Shigeyuki, Tsuda, Kengo, Takaho Terada, Shigeyuki Yokoyama, Tanaka, Akiko, Güntert, Peter   +27 more
core   +2 more sources

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Jamshidi S, Eghbalian A, Shojaei S, Taherkhani A, Feizi-Dehnayebi M.   +4 more
europepmc   +2 more sources

BP1 bipedal trackway measurements.

, 2020
BP1 bipedal trackway measurements.
Dugald A. Ross (5027426), Thomas J. Challands (5016698), Paige E. dePolo (5016707), Jon Hoad (8561595), Paulo Victor Luiz Gomes da Costa Pereira (5579489), Davide Foffa (4494211), Mark Wilkinson (75901), Neil D. L. Clark (8561592), Thomas J. Wade (8561598), Stephen L. Brusatte (8561589)   +9 more
core   +1 more source

APP-BP1 Inhibits Aβ42 Levels by Interacting with Presenilin-1 [PDF]

, 2007
Background: The β-amyloid precursor protein (APP) is sequentially cleaved by the β- and then γ-secretase to generate the amyloid β-peptides Aβ40 and Aβ42. Increased Aβ42/Aβ40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD). APP binds
Chen, Yuzhi, Neve, Rachael L, Bodles, Angela M, W Sue T Griffin, Griffin, W Sue T, McPhie, Donna, Yuzhi Chen, Donna L McPhie, Rachael L Neve, Mrak, Robert E, Angela M Bodles, Robert E Mrak   +11 more
core   +1 more source

Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1

, 2009
Current accepted models suggest that hypophosphorylated 4E-binding protein (4E-BP1) binds to initiationfactor 4E (eIF4E) to inhibit cap-dependent translation, a process readily reversed by its phosphorylationfollowing activation of mammalian target of ...
Markete Vlasak, Joanne L. Cowan, Mark Willett (16063460), Simon Morley (4460458), Willett, Mark, Markete Vlasak (16088261), Coldwell, Mark J., Cowan, Joanne L., Simon J. Morley, Vlasak, Markete, Morley, Simon J., Mark Willett, Mark J. Coldwell, Mark J Coldwell (16062002), Joanne L Cowan (16079609)   +14 more
core   +1 more source

HUMAN RELATION DALAM PERSPEKTIF ISLAM

Hunafa: Jurnal Studia Islamika, 2008
Human relation in a contemporary management, which places human beings in a proportional position, is so important that it should be paid serious attention. In Islamic perspective, human relation also emphasizes human beings as the most honored creatures
Andi Zuchairini
doaj   +1 more source