Results 1 to 10 of about 49,831 (180)

A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties. [PDF]

Small Sci
Peroxidase is a heme‐containing enzyme that has been broadly used in medical diagnosis, environmental treatments, and chemical syntheses. Its main limitation is low expression yields and poor stability in harsh environments. Herein, the feasibility and the use of Stable protein 1, a thermo‐stable and stress‐responsive protein, conjugated with hemin as ...
Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O.   +4 more
europepmc   +2 more sources

Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. [PDF]

FEBS Open Bio
Hepatocytes can switch their metabolic processes in response to nutrient availability. We visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose‐deprivation. Glucose administration to hepatocytes under glucose deprivation conditions can cause an immediate decrease in the mitochondrial ATP concentration. In contrast,
Tsuno S, Harada K, Horikoshi M, Mita M, Kitaguchi T, Hirai MY, Matsumoto M, Tsuboi T.   +7 more
europepmc   +2 more sources

Reinforcer value moderates response magnitude and persistence during extinction: A randomized trial. [PDF]

J Appl Behav Anal
Abstract Extinction bursts, or temporary increases in rates and intensities of behavior during extinction, can preclude the inclusion of extinction in intervention packages meant to suppress severe challenging behavior. To identify underlying behavioral mechanisms responsible for response persistence and bursting, 69 adults with developmental ...
Lambert JM, Osina MA, Copeland BA.
europepmc   +2 more sources

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Jamshidi S, Eghbalian A, Shojaei S, Taherkhani A, Feizi-Dehnayebi M.   +4 more
europepmc   +2 more sources

Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects

Cell Chemical Biology, 2019
Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor progression. Here, we identify the prototypical pyranonaphthoquinone natural product frenolicin B (FB)
Yi-Nan Zhang, Xia-Chang Wang, Larissa V Ponomareva   +2 more
exaly   +2 more sources

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review. [PDF]

Photochem Photobiol
Conventional treatments for various types of cancer are often associated with tumor recurrence and aggressiveness. Photobiomodulation with blue light (BL; 450–470 nm) emerges as a promising alternative with antitumor effects. This systematic review, with 37 in vitro and in vivo studies from 2002 to 2024, revealed that BL reduces cell viability ...
de Lima BES, Nascimento RB, Ginez APMS, Moreira MS, Cecatto RB, Marcos RL, Rodrigues MFSD.   +6 more
europepmc   +2 more sources

Prader–Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review

International Journal of Molecular Sciences, 2023
Prader–Willi syndrome (PWS) is a complex genetic disorder with three PWS molecular genetic classes and presents as severe hypotonia, failure to thrive, hypogonadism/hypogenitalism and developmental delay during infancy. Hyperphagia, obesity, learning and
M. Butler
semanticscholar   +1 more source

SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1

Journal of Biological Chemistry, 2023
Breast cancer stem cells are mainly responsible for poor prognosis, especially in triple-negative breast cancer (TNBC). In a previous study, we demonstrated that ε-Sarcoglycan (SGCE), a type Ⅰ single-transmembrane protein, is a potential oncogene that ...
Ting Qiu, Lei Hou, Lina Zhao, Xinye Wang, Zhongmei Zhou, Chuanyu Yang, Huifeng Zhang, Dewei Jiang, B. Jiao, Ceshi Chen   +9 more
semanticscholar   +1 more source

The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.

Molecules and Cells, 2021
The activation of cap-dependent translation in eukaryotes requires multisite, hierarchical phosphorylation of 4E-BP by the 1 MDa kinase mammalian target of rapamycin complex 1 (mTORC1). To resolve the mechanism of this hierarchical phosphorylation at the
R. Böhm, S. Imseng, R. Jakob, M. Hall, T. Maier, S. Hiller   +5 more
semanticscholar   +1 more source

4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis

Protein & Cell, 2022
Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown.
Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin, Yiyuan Zhang, Sheng Zhang, Xiaoqian Liu, Weiqi Zhang, Guang-Hui Liu, Si Wang, Moshi Song, J. Qu   +12 more
semanticscholar   +1 more source