Results 11 to 20 of about 44,175 (160)

A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties. [PDF]

Small Sci
Peroxidase is a heme‐containing enzyme that has been broadly used in medical diagnosis, environmental treatments, and chemical syntheses. Its main limitation is low expression yields and poor stability in harsh environments. Herein, the feasibility and the use of Stable protein 1, a thermo‐stable and stress‐responsive protein, conjugated with hemin as ...
Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O.   +4 more
europepmc   +2 more sources

Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. [PDF]

FEBS Open Bio
Hepatocytes can switch their metabolic processes in response to nutrient availability. We visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose‐deprivation. Glucose administration to hepatocytes under glucose deprivation conditions can cause an immediate decrease in the mitochondrial ATP concentration. In contrast,
Tsuno S, Harada K, Horikoshi M, Mita M, Kitaguchi T, Hirai MY, Matsumoto M, Tsuboi T.   +7 more
europepmc   +2 more sources

Reinforcer value moderates response magnitude and persistence during extinction: A randomized trial. [PDF]

J Appl Behav Anal
Abstract Extinction bursts, or temporary increases in rates and intensities of behavior during extinction, can preclude the inclusion of extinction in intervention packages meant to suppress severe challenging behavior. To identify underlying behavioral mechanisms responsible for response persistence and bursting, 69 adults with developmental ...
Lambert JM, Osina MA, Copeland BA.
europepmc   +2 more sources

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

MedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An, Lunzhi Dai   +10 more
wiley   +1 more source

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

MedComm, Volume 4, Issue 3, June 2023., 2023
Cao et al. provide a comprehensive overview of signaling pathways in the pathogenesis and therapy of type 2 diabetes mellitus (T2DM) and its complications. Abstract Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for a broad range of comorbidities, including ...
Rong Cao, Huimin Tian, Yu Zhang, Geng Liu, Haixia Xu, Guocheng Rao, Yan Tian, Xianghui Fu   +7 more
wiley   +1 more source

Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment

Aging Cell, Volume 22, Issue 4, April 2023., 2023
Genetically diverse HET3 mice display sex‐dependent peripheral neuropathy phenotypes as a result of age. Longevity treatment rapamycin was unable to attenuate denervation and worsened adipose tissue inflammation and fibrosis. Abstract Neural communication between the brain and adipose tissues regulates energy expenditure and metabolism through ...
Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina DiPietro, Emma Paradie, Benjamin Tero, Anne Harrington, Larisa Ryzhova, Lucy Liaw, Peter C. Reifsnyder, David E. Harrison, Kristy L. Townsend   +16 more
wiley   +1 more source

Nanoarchitectonics of Two‐Dimensional Electrochromic Materials: Achievements and Future Challenges

Advanced Materials Technologies, Volume 8, Issue 4, February 24, 2023., 2023
This review highlights the recent achievements of emerging 2D electrochromic materials, namely covalent organic frameworks, coordination nanosheets, and transition metal carbides/nitrides/carbonitrides (MXenes). The structures, electrochromic performances and their structure–performance relationship, and future challenges of these materials have been ...
Meng Li, Zhenzhen Wu, Yuhui Tian, Feng Pan, Tim Gould, Shanqing Zhang   +5 more
wiley   +1 more source

Kur’ân’ın İkrar Ettiği İbrahimî Bir Hac Geleneği: Kalâid

Cumhuriyet İlahiyat Dergisi, 2019
Kur’ân’ın nazil olduğu sırada Arapların edasına önem verdiği en mühim ibadetin Hz. İbrahim’den tevarüs ettikleri hac olduğu görülmektedir. Umumi manada Kâbe ziyareti ile kurban takdimini ifade eden hac, Allah’a takarrübün en büyük vesilesi kabul ...
Muhammed Selman Çalışkan
doaj   +1 more source

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Jamshidi S, Eghbalian A, Shojaei S, Taherkhani A, Feizi‐Dehnayebi M.   +4 more
europepmc   +2 more sources

A Comprehensive Assessment of Indoor Air Quality and Thermal Comfort in Educational Buildings in the Mediterranean Climate

Indoor Air, Volume 2023, Issue 1, 2023., 2023
Maintaining good indoor air quality and thermal comfort is a challenge for naturally ventilated educational buildings, as it can be difficult to achieve both aspects simultaneously. Nonetheless, most of the existing studies only focus on one aspect.
S. Miao, M. Gangolells, B. Tejedor, Shah Fahad   +3 more
wiley   +1 more source