Results 11 to 20 of about 36,655 (113)

A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties. [PDF]

Small Sci
Peroxidase is a heme‐containing enzyme that has been broadly used in medical diagnosis, environmental treatments, and chemical syntheses. Its main limitation is low expression yields and poor stability in harsh environments. Herein, the feasibility and the use of Stable protein 1, a thermo‐stable and stress‐responsive protein, conjugated with hemin as ...
Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O.   +4 more
europepmc   +2 more sources

Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. [PDF]

FEBS Open Bio
Hepatocytes can switch their metabolic processes in response to nutrient availability. We visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose‐deprivation. Glucose administration to hepatocytes under glucose deprivation conditions can cause an immediate decrease in the mitochondrial ATP concentration. In contrast,
Tsuno S, Harada K, Horikoshi M, Mita M, Kitaguchi T, Hirai MY, Matsumoto M, Tsuboi T.   +7 more
europepmc   +2 more sources

Prader–Willi Syndrome and Chromosome 15q11.2 BP1-BP2 Region: A Review

International Journal of Molecular Sciences, 2023
Prader–Willi syndrome (PWS) is a complex genetic disorder with three PWS molecular genetic classes and presents as severe hypotonia, failure to thrive, hypogonadism/hypogenitalism and developmental delay during infancy. Hyperphagia, obesity, learning and
M. Butler
semanticscholar   +1 more source

Reinforcer value moderates response magnitude and persistence during extinction: A randomized trial. [PDF]

J Appl Behav Anal
Abstract Extinction bursts, or temporary increases in rates and intensities of behavior during extinction, can preclude the inclusion of extinction in intervention packages meant to suppress severe challenging behavior. To identify underlying behavioral mechanisms responsible for response persistence and bursting, 69 adults with developmental ...
Lambert JM, Osina MA, Copeland BA.
europepmc   +2 more sources

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Jamshidi S, Eghbalian A, Shojaei S, Taherkhani A, Feizi-Dehnayebi M.   +4 more
europepmc   +2 more sources

4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis

Protein & Cell, 2022
Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown.
Yifang He, Qianzhao Ji, Zeming Wu, Yusheng Cai, Jian Yin, Yiyuan Zhang, Sheng Zhang, Xiaoqian Liu, Weiqi Zhang, Guang-Hui Liu, Si Wang, Moshi Song, J. Qu   +12 more
semanticscholar   +1 more source

Fusarium BP1 is a reader of H3K27 methylation

Nucleic Acids Research, 2021
Histone H3 lysine 27 methylation catalyzed by polycomb repressive complex 2 (PRC2) is conserved from fungi to humans and represses gene transcription. However, the mechanism for recognition of methylated H3K27 remains unclear, especially in fungi.
G. Tang, Jianlong Yuan, Jing Wang, Yi-Zhe Zhang, Sijie Xie, Hongkai Wang, Zeng Tao, Huiquan Liu, H. Kistler, Youfu Zhao, Cheng-Guo Duan, Wende Liu, Zhonghua Ma, Yun Chen   +13 more
semanticscholar   +1 more source

Genomic, Clinical, and Behavioral Characterization of 15q11.2 BP1-BP2 Deletion (Burnside-Butler) Syndrome in Five Families

International Journal of Molecular Sciences, 2021
The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most common cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing.
Isaac Baldwin, Robin L. Shafer, Waheeda A. Hossain, S. Gunewardena, Olivia J. Veatch, Matthew W. Mosconi, M. Butler   +6 more
semanticscholar   +1 more source

BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1

FEBS Open Bio, 2021
More than 40 000 patients worldwide die from esophageal cancer annually. The 5‐year survival rate of patients is only ~ 15–20%, and thus, there is an ongoing need to improve diagnosis and treatment of esophageal cancer.
Fengyun Wang, Ming Luo, Honglan Qu, Yufeng Cheng   +3 more
semanticscholar   +1 more source

Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition.

JAMA psychiatry, 2020
Importance Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders.
D. van der Meer, I. Sønderby, T. Kaufmann, G. Walters, A. Abdellaoui, D. Ames, K. Amunts, M. Andersson, N. Armstrong, M. Bernard, Nicholas B. Blackburn, J. Blangero, D. Boomsma, H. Brodaty, R. Brouwer, R. Bülow, W. Cahn, V. Calhoun, S. Caspers, G. Cavalleri, C. Ching, S. Cichon, S. Ciufolini, A. Corvin, B. Crespo-Facorro, J. Curran, S. Dalvie, P. Dazzan, E. D. de Geus, G. D. de Zubicaray, S. D. de Zwarte, N. Delanty, Anouk den Braber, S. Desrivières, M. di Forti, J. Doherty, G. Donohoe, S. Ehrlich, E. Eising, T. Espeseth, S. Fisher, T. Fladby, O. Frei, V. Frouin, M. Fukunaga, Thomas Gareau, D. Glahn, H. Grabe, N. Groenewold, Ó. Gústafsson, J. Haavik, A. Håberg, R. Hashimoto, J. Hehir-Kwa, D. Hibar, M. Hillegers, P. Hoffmann, L. Holleran, J. Hottenga, H. H. Hulshoff Pol, M. Ikeda, S. Jacquemont, N. Jahanshad, C. Jockwitz, S. Johansson, E. Jönsson, M. Kikuchi, E. Knowles, J. Kwok, S. Le Hellard, D. Linden, Jingyu Liu, A. Lundervold, A. Lundervold, N. Martin, K. Mather, S. Mathias, K. Mcmahon, A. McRae, S. Medland, T. Moberget, C. Moreau, D. Morris, Thomas W. Mühleisen, R. Murray, J. Nordvik, L. Nyberg, Loes M. Olde Loohuis, R. Ophoff, M. Owen, T. Paus, Z. Pausova, J. Peralta, B. Pike, Carlos Prieto, E. Quinlan, C. Reinbold, T. Reis Marques, J. Rucker, P. Sachdev, S. Sando, P. Schofield, A. Schork, G. Schumann, Jean Shin, E. Shumskaya, Ana I. Silva, S. Sisodiya, V. Steen, Dan J Stein, Lachlan T. Strike, C. K. Tamnes, A. Teumer, A. Thalamuthu, D. Tordesillas-Gutiérrez, A. Uhlmann, M. Ulfarsson, D. van ‘t Ent, M. V. D. van den Bree, E. Vassos, W. Wen, K. Wittfeld, M. Wright, T. Zayats, A. Dale, S. Djurovic, I. Agartz, L. Westlye, H. Stefánsson, K. Stefánsson, P. Thompson, O. Andreassen   +131 more
semanticscholar   +1 more source