Results 11 to 20 of about 43,290 (163)

A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties. [PDF]

Small Sci
Peroxidase is a heme‐containing enzyme that has been broadly used in medical diagnosis, environmental treatments, and chemical syntheses. Its main limitation is low expression yields and poor stability in harsh environments. Herein, the feasibility and the use of Stable protein 1, a thermo‐stable and stress‐responsive protein, conjugated with hemin as ...
Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O.   +4 more
europepmc   +2 more sources

Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. [PDF]

FEBS Open Bio
Hepatocytes can switch their metabolic processes in response to nutrient availability. We visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose‐deprivation. Glucose administration to hepatocytes under glucose deprivation conditions can cause an immediate decrease in the mitochondrial ATP concentration. In contrast,
Tsuno S, Harada K, Horikoshi M, Mita M, Kitaguchi T, Hirai MY, Matsumoto M, Tsuboi T.   +7 more
europepmc   +2 more sources

Reinforcer value moderates response magnitude and persistence during extinction: A randomized trial. [PDF]

J Appl Behav Anal
Abstract Extinction bursts, or temporary increases in rates and intensities of behavior during extinction, can preclude the inclusion of extinction in intervention packages meant to suppress severe challenging behavior. To identify underlying behavioral mechanisms responsible for response persistence and bursting, 69 adults with developmental ...
Lambert JM, Osina MA, Copeland BA.
europepmc   +2 more sources

Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells. [PDF]

FEBS Open Bio, 2022
In this study, we provide evidence suggesting potential adaptive mechanisms that are activated in response to dysfunction of mitochondrial complex IV in HCT116 colon cancer cell line. These mechanisms involve dramatic metabolic reprogramming to compensate for the disruption of mitochondrial functions that is accompanied by the activation of the IGF1R ...
Uchenunu O, Zhdanov AV, Hutton P, Jovanovic P, Wang Y, Andreev DE, Hulea L, Papadopoli DJ, Avizonis D, Baranov PV, Pollak MN, Papkovsky DB, Topisirovic I.   +12 more
europepmc   +2 more sources

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

MedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An, Lunzhi Dai   +10 more
wiley   +1 more source

Advancements in B-Cell Non-Hodgkin's Lymphoma: From Signaling Pathways to Targeted Therapies. [PDF]

Adv Hematol
Lymphoma is the sixth most prevalent cancer globally. Non‐Hodgkin’s lymphomas are the majority group of lymphomas, with B cells accounting for approximately 95% of these lymphomas. A key feature of B‐cell lymphoma is the functional perturbations of essential biological pathways caused by genetic aberrations.
Alfaifi A, Bahashwan S, Alsaadi M, Ageel AH, Ahmed HH, Fatima K, Malhan H, Qadri I, Almehdar H.   +8 more
europepmc   +2 more sources

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

MedComm, Volume 4, Issue 3, June 2023., 2023
Cao et al. provide a comprehensive overview of signaling pathways in the pathogenesis and therapy of type 2 diabetes mellitus (T2DM) and its complications. Abstract Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for a broad range of comorbidities, including ...
Rong Cao, Huimin Tian, Yu Zhang, Geng Liu, Haixia Xu, Guocheng Rao, Yan Tian, Xianghui Fu   +7 more
wiley   +1 more source

Age‐related changes to adipose tissue and peripheral neuropathy in genetically diverse HET3 mice differ by sex and are not mitigated by rapamycin longevity treatment

Aging Cell, Volume 22, Issue 4, April 2023., 2023
Genetically diverse HET3 mice display sex‐dependent peripheral neuropathy phenotypes as a result of age. Longevity treatment rapamycin was unable to attenuate denervation and worsened adipose tissue inflammation and fibrosis. Abstract Neural communication between the brain and adipose tissues regulates energy expenditure and metabolism through ...
Jake W. Willows, Morganne Robinson, Zahra Alshahal, Samantha K. Morrison, Gargi Mishra, Harrison Cyr, Magdalena Blaszkiewicz, Gilian Gunsch, Sabrina DiPietro, Emma Paradie, Benjamin Tero, Anne Harrington, Larisa Ryzhova, Lucy Liaw, Peter C. Reifsnyder, David E. Harrison, Kristy L. Townsend   +16 more
wiley   +1 more source

Nanoarchitectonics of Two‐Dimensional Electrochromic Materials: Achievements and Future Challenges

Advanced Materials Technologies, Volume 8, Issue 4, February 24, 2023., 2023
This review highlights the recent achievements of emerging 2D electrochromic materials, namely covalent organic frameworks, coordination nanosheets, and transition metal carbides/nitrides/carbonitrides (MXenes). The structures, electrochromic performances and their structure–performance relationship, and future challenges of these materials have been ...
Meng Li, Zhenzhen Wu, Yuhui Tian, Feng Pan, Tim Gould, Shanqing Zhang   +5 more
wiley   +1 more source

HAWC J2227+610 and Its Association with G106.3+2.7, a New Potential Galactic PeVatron [PDF]

Astrophysical Journal, 2020
We present the detection of very-high-energy gamma-ray emission above 100 TeV from HAWC J2227+610 with the High-Altitude Water Cherenov Gamma-Ray Observatory (HAWC) observatory.
A. Albert, R. Alfaro, C. Alvarez, J. Camacho, J. C. Arteaga-Vel'azquez, K. Arunbabu, D. Rojas, H. Solares, V. Baghmanyan, E. Belmont-Moreno, S. Benzvi, C. Brisbois, K. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. León, E. D. L. Fuente, L. Díaz-Cruz, B. Dingus, M. DuVernois, J. C. Díaz-Vélez, R. Ellsworth, K. Engel, C. Espinoza, K. Fan, K. Fang, M. F. Alonso, H. Fleischhack, N. Fraija, A. Galv'an-G'amez, D. García, J. García-González, F. Garfias, G. Giacinti, M. Gonz'alez, J. Goodman, J. P. Harding, S. Hernández, J. Hinton, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, William H. Lee, H. L. Vargas, J. Linnemann, A. Longinotti, G. Luis-Raya, J. Lundeen, K. Malone, S. Marinelli, O. Martinez, I. Martinez-Castellanos, J. Martínez-Castro, J. Matthews, P. Miranda-Romagnoli, J. Morales-Soto, E. Moreno, M. Mostafá, A. Nayerhoda, L. Nellen, M. Newbold, M. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. Araujo, E. Pérez-Pérez, C. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, F. Greus, A. Sandoval, Michael Schneider, H. Schoorlemmer, J. S. Franco, G. Sinnis, A. Smith, R. Springer, P. Surajbali, E. Tabachnick, M. Tanner, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, F. Ureña-Mena, L. Villaseñor, T. Weisgarber, A. Zepeda, Hong-lei Zhou, C. D. Le'on, J. Álvarez   +99 more
semanticscholar   +1 more source