Results 11 to 20 of about 49,552 (162)

A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties. [PDF]

Small Sci
Peroxidase is a heme‐containing enzyme that has been broadly used in medical diagnosis, environmental treatments, and chemical syntheses. Its main limitation is low expression yields and poor stability in harsh environments. Herein, the feasibility and the use of Stable protein 1, a thermo‐stable and stress‐responsive protein, conjugated with hemin as ...
Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O.   +4 more
europepmc   +2 more sources

Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes. [PDF]

FEBS Open Bio
Hepatocytes can switch their metabolic processes in response to nutrient availability. We visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose‐deprivation. Glucose administration to hepatocytes under glucose deprivation conditions can cause an immediate decrease in the mitochondrial ATP concentration. In contrast,
Tsuno S, Harada K, Horikoshi M, Mita M, Kitaguchi T, Hirai MY, Matsumoto M, Tsuboi T.   +7 more
europepmc   +2 more sources

Reinforcer value moderates response magnitude and persistence during extinction: A randomized trial. [PDF]

J Appl Behav Anal
Abstract Extinction bursts, or temporary increases in rates and intensities of behavior during extinction, can preclude the inclusion of extinction in intervention packages meant to suppress severe challenging behavior. To identify underlying behavioral mechanisms responsible for response persistence and bursting, 69 adults with developmental ...
Lambert JM, Osina MA, Copeland BA.
europepmc   +2 more sources

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Jamshidi S, Eghbalian A, Shojaei S, Taherkhani A, Feizi-Dehnayebi M.   +4 more
europepmc   +2 more sources

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

MedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An, Lunzhi Dai   +10 more
wiley   +1 more source

The 15q11.2 BP1-BP2 Microdeletion (Burnside–Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Disorders

International Journal of Molecular Sciences, 2020
The 15q11.2 BP1-BP2 microdeletion (Burnside–Butler) syndrome is emerging as the most frequent pathogenic copy number variation (CNV) in humans associated with neurodevelopmental disorders with changes in brain morphology, behavior, and cognition. In this
Syed K. Rafi, M. Butler
semanticscholar   +1 more source

MATURIDIYAH: KELAHIRAN DAN PERKEMBANGANNYA

Hunafa: Jurnal Studia Islamika, 2007
In discourse of theological thought, the Matturidite and the Asy’arite popularly known as Ahl al-Sunnah wal al-Jama’ah, are two schools of Islamic theology that tried to take the middle path between the conservative theological thought and the rational ...
Hamka Hamka
doaj   +1 more source

HAWC J2227+610 and Its Association with G106.3+2.7, a New Potential Galactic PeVatron [PDF]

Astrophysical Journal, 2020
We present the detection of very-high-energy gamma-ray emission above 100 TeV from HAWC J2227+610 with the High-Altitude Water Cherenov Gamma-Ray Observatory (HAWC) observatory.
A. Albert, R. Alfaro, C. Alvarez, J. Camacho, J. C. Arteaga-Vel'azquez, K. Arunbabu, D. Rojas, H. Solares, V. Baghmanyan, E. Belmont-Moreno, S. Benzvi, C. Brisbois, K. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. León, E. D. L. Fuente, L. Díaz-Cruz, B. Dingus, M. DuVernois, J. C. Díaz-Vélez, R. Ellsworth, K. Engel, C. Espinoza, K. Fan, K. Fang, M. F. Alonso, H. Fleischhack, N. Fraija, A. Galván-Gámez, D. García, J. García-González, F. Garfias, G. Giacinti, M. Gonz'alez, J. Goodman, J. P. Harding, S. Hernández, J. Hinton, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, William H. Lee, H. L. Vargas, J. Linnemann, A. Longinotti, G. Luis-Raya, J. Lundeen, K. Malone, S. Marinelli, O. Martinez, I. Martinez-Castellanos, J. Martínez-Castro, J. Matthews, P. Miranda-Romagnoli, J. Morales-Soto, E. Moreno, M. Mostafá, A. Nayerhoda, L. Nellen, M. Newbold, M. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. Araujo, E. Pérez-Pérez, C. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, F. Greus, A. Sandoval, M. Schneider, H. Schoorlemmer, J. S. Franco, G. Sinnis, A. Smith, R. Springer, P. Surajbali, E. Tabachnick, M. Tanner, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, F. Ureña-Mena, L. Villaseñor, T. Weisgarber, A. Zepeda, Hong-lei Zhou, C. D. Le'on, J. Álvarez   +99 more
semanticscholar   +1 more source

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

Nature Communications, 2019
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR
Hannah V. Woodcock, J. Eley, D. Guillotin, M. Platé, C. Nanthakumar, Matteo Martufi, Simon Peace, G. Joberty, Daniel Poeckel, R. Good, Adam R. Taylor, N. Zinn, Matthew Redding, E. Forty, R. Hynds, C. Swanton, M. Karsdal, T. Maher, Andrew Fisher, G. Bergamini, R. Marshall, A. Blanchard, P. Mercer, R. Chambers   +23 more
semanticscholar   +1 more source

JAMINAN SOSIAL DALAM PANDANGAN IBNU HAZM DAN RELEVANSINYA DENGAN PENGEMBANGAN JAMINAN SOSIAL DI INDONESIA

Hunafa: Jurnal Studia Islamika, 2015
This research is library research that discusses the thought of Ibn Hazm. This research focuses on the study of the methodology of ijtihad of Ibn Hazm. One of the themes of ijtihad of Ibn Hazm  can still, up to the present, be considered is his concept ...
Atik Wartini
doaj   +1 more source