Results 31 to 40 of about 36,655 (113)

Diabetes enhances translation of Cd40 mRNA in murine retinal Müller glia via a 4E-BP1/2–dependent mechanism

Journal of Biological Chemistry, 2020
Activation of the immune costimulatory molecule cluster of differentiation 40 (CD40) in Müller glia has been implicated in the initiation of diabetes-induced retinal inflammation.
Sadie K. Dierschke, Allyson L. Toro, William P. Miller, Siddharth Sunilkumar, Michael D. Dennis   +4 more
semanticscholar   +1 more source

Treatment-resistant psychotic symptoms and the 15q11.2 BP1–BP2 (Burnside-Butler) deletion syndrome: case report and review of the literature

Translational Psychiatry, 2020
The 15q11.2 BP1-BP2 (Burnside-Butler) deletion is a rare copy number variant impacting four genes ( NIPA1, NIPA2, CYFIP1, and TUBGCP5 ), and carries increased risks for developmental delay, intellectual disability, and neuropsychiatric disorders ...
M. Farrell, M. Lichtenstein, M. Harner, J. Crowley, Dawn M. Filmyer, G. Lázaro-Muñoz, T. Dietterich, L. Bruno, R. Shaughnessy, Tamara F. Biondi, Stephan Burkholder, Jane Donmoyer, J. Berg, J. Szatkiewicz, P. Sullivan, R. Josiassen   +15 more
semanticscholar   +1 more source

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.

Cancer Research, 2019
Aberrant activation of the PI3K-mTOR signaling pathway occurs in >80% of head and neck squamous cell carcinomas (HNSCC), and overreliance on this signaling circuit may in turn represent a cancer-specific vulnerability that can be exploited ...
Zhiyong Wang, Xiaodong Feng, A. Molinolo, Daniel Martin, L. Vitale-Cross, N. Nohata, Mizuo Ando, Amy Wahba, Panomwat Amornphimoltham, Xingyu Wu, M. Gilardi, M. Allevato, Victoria H. Wu, Dana J. Steffen, P. Tofilon, N. Sonenberg, J. Califano, Qianming Chen, S. Lippman, J. Gutkind   +19 more
semanticscholar   +1 more source

Should We Report 15q11.2 BP1-BP2 Deletions and Duplications in the Prenatal Setting?

Journal of Clinical Medicine, 2020
Copy number variations of the 15q11.2 region at breakpoints 1-2 (BP1-BP2) have been associated with variable phenotypes and low penetrance. Detection of such variations in the prenatal setting can result in significant parental anxiety.
I. Maya, S. Perlman, M. Shohat, S. Kahana, S. Yacobson, T. Tenne, Ifaat Agmon-Fishman, Reut Tomashov Matar, L. Basel-Salmon, R. Sukenik-Halevy   +9 more
semanticscholar   +1 more source

Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours

Nature Communications, 2018
Aberrant expression of long noncoding RNA H19 has been associated with tumour progression, but the underlying molecular tumourigenesis mechanisms remain largely unknown.
Z. Wu, Lichong Yan, Yan ting Liu, Lei Cao, Y. Guo, Yong Zhang, Hong Yao, Lin Cai, H. Shang, W. Rui, Gang Yang, Xiao Zhang, Hao Tang, Yu Wang, J. Huang, Y. Wei, W. Zhao, Bing Su, Zhengzheng Wu   +18 more
semanticscholar   +1 more source

Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression

Genome Biology
Bromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation of lysine 27 in histone H3 (H3K27me3), an epigenetic hallmark of gene silencing ...
G. Tang, Haoxue Xia, Yufei Huang, Yuanwen Guo, Yun Chen, Zhonghua Ma, Wende Liu   +6 more
semanticscholar   +1 more source

Vanillic Acid Suppresses HIF-1α Expression via Inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK Pathways in Human Colon Cancer HCT116 Cells

International Journal of Molecular Sciences, 2019
Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor development.
Jingli Gong, Shengxue Zhou, Shihai Yang
semanticscholar   +1 more source

Harnessing blue light photobiomodulation for cancer therapy: Evidence from a systematic review

Photochemistry and Photobiology, EarlyView.
Conventional treatments for various types of cancer are often associated with tumor recurrence and aggressiveness. Photobiomodulation with blue light (BL; 450–470 nm) emerges as a promising alternative with antitumor effects. This systematic review, with 37 in vitro and in vivo studies from 2002 to 2024, revealed that BL reduces cell viability ...
Bárbara Evelyn Santos de Lima, Rebeca Barros Nascimento, Ana Paula Mariano Santos Ginez, Maria Stella Moreira, Rebeca Boltes Cecatto, Rodrigo Labat Marcos, Maria Fernanda Setúbal Destro Rodrigues   +6 more
wiley   +1 more source

Geomagnetic Variability in a Post‐Superchron Geodynamo: Insights From the Deccan Traps

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 1, January 2026.
Abstract Studying long‐term geomagnetic field behavior is crucial for understanding Earth's evolution, as field variability reflects processes in the planet's deep interior. One key question concerns the relationship between field strength and polarity reversal frequency, particularly during the Cretaceous Normal Superchron (CNS), a prolonged interval ...
K. E. Bristol, C. J. Sprain, T. Mittal, A. Monteiro, R. Duraiswami, M. M. Tremblay, M. Mijjum   +6 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source