Results 31 to 40 of about 43,290 (163)
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
Nature Communications, 2019 Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/mTOR
Hannah V. Woodcock +23 more
semanticscholar +1 more source
Should We Report 15q11.2 BP1-BP2 Deletions and Duplications in the Prenatal Setting?
Journal of Clinical Medicine, 2020 Copy number variations of the 15q11.2 region at breakpoints 1-2 (BP1-BP2) have been associated with variable phenotypes and low penetrance. Detection of such variations in the prenatal setting can result in significant parental anxiety.
I. Maya +9 more
semanticscholar +1 more source
Translational Psychiatry, 2020 The 15q11.2 BP1-BP2 (Burnside-Butler) deletion is a rare copy number variant impacting four genes ( NIPA1, NIPA2, CYFIP1, and TUBGCP5 ), and carries increased risks for developmental delay, intellectual disability, and neuropsychiatric disorders ...
M. Farrell +15 more
semanticscholar +1 more source
CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability
Genes & Development, 2019 Here, Choi et al. show that CDK12, the RNA polymerase II C-terminal domain kinase, which regulates genome stability, expression of DNA repair genes, and cancer cell drug resistance, also phosphorylates the mRNA 5′ cap-binding repressor 4E-BP1 to promote ...
S. Choi +6 more
semanticscholar +1 more source
Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
Nature Communications, 2018 Aberrant expression of long noncoding RNA H19 has been associated with tumour progression, but the underlying molecular tumourigenesis mechanisms remain largely unknown.
Z. Wu +18 more
semanticscholar +1 more source
4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.
Cancer Research, 2019 Aberrant activation of the PI3K-mTOR signaling pathway occurs in >80% of head and neck squamous cell carcinomas (HNSCC), and overreliance on this signaling circuit may in turn represent a cancer-specific vulnerability that can be exploited ...
Zhiyong Wang +19 more
semanticscholar +1 more source
Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression
Genome BiologyBackground Bromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi.
G. Tang +6 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2019 Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor development.
Jingli Gong, Shengxue Zhou, Shihai Yang
semanticscholar +1 more source
SEMANTIC APPROACH (BAYANI) IN ISLAMIC STUDIES
Hunafa: Jurnal Studia Islamika, 2021 The Semantic Approach (Bayani) is an approach in the study of Islamic studies to comprehend Islam comprehensively. This research refers to some literature related to the semantic approach.
Muhammad Wahdini
doaj +1 more source
THE CONTEXTUALIZATION OF THE TRADITIONAL ISLAMIC BOOK ON CONTEMPORARY ISSUES
Hunafa: Jurnal Studia Islamika, 2021 This research is a research library, and belongs to qualitative research. The research approach is used with a normative approach. The results reveal that the role of the traditional islamic book is still very important and contextual. The use of analogy
Safriadi Safriadi
doaj +1 more source