Results 81 to 90 of about 44,175 (160)

Upregulation of the Nitrosylome in Bipolar Disorder Type 1 (BP1), but not BP2, and Major Depression: Increased IgM Antibodies to Nitrosylated Conjugates are Associated with Indicants of Leaky Gut

, 2019
Objective: Major depression (MDD) and a lifetime history of MDD are characterized by increased nitrosylation, while bipolar disorder type 1 (BP1), but not BP2, is accompanied by highly increased levels of oxidative stress and nitric oxide (NO) production.
M. Maes, D. Simeonova, D. Stoyanov, J. Leunis   +3 more
semanticscholar   +1 more source

The consequences of increased 4E-BP1 in polycystic kidney disease.

Human Molecular Genetics, 2019
Autosomal Dominant Polycystic kidney disease (ADPKD) is the most common hereditary renal disease, characterized by cyst formation and growth. Hyperproliferation is a major contributor to cyst growth.
S. Holditch, C. N. Brown, Daniel J. Atwood, Deepak Pokhrel, Sara E. Brown, A. M. Lombardi, Khoa N. Nguyen, Ryan C. Hill, M. Lanaspa, Katharina Hopp, M. Weiser-Evans, C. Edelstein   +11 more
semanticscholar   +1 more source

The 15q11.2 BP1–BP2 Microdeletion Syndrome: A Review

International Journal of Molecular Sciences, 2015
Patients with the 15q11.2 BP1–BP2 microdeletion can present with developmental and language delay, neurobehavioral disturbances and psychiatric problems. Autism, seizures, schizophrenia and mild dysmorphic features are less commonly seen. The 15q11.2 BP1–
Devin M Cox, M. Butler
semanticscholar   +1 more source

Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats.

Molecular Medicine Reports, 2018
The aim of the present study was to determine the effects of ferulic acid (FerA) administered immediately following the onset of permanent middle cerebral artery occlusion (MCAo) and then 7 days of ischemia, and also to explore the involvement of protein
Chin-Yi Cheng, S. Kao, Yu-Chen Lee
semanticscholar   +1 more source

Telaah Hukum Islam terhadap Nasab Anak

Hunafa: Jurnal Studia Islamika, 2016
The classical scholars of jurisprudence agreed that nasab child has only nasab relationship to his parents, nasab determination is one of the most important rights of a child and is something that a lot of impact on the child's personality and future ...
Sakirman Sakirman
doaj   +1 more source

Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy.

Brain : a journal of neurology, 2021
Lena H. Nguyen, Youfen Xu, Travorn Mahadeo, Longbo Zhang, Tiffany V. Lin, Heather A. Born, Anne E. Anderson, A. Bordey   +7 more
semanticscholar   +1 more source

Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

EMBO Molecular Medicine, 2015
Pancreatic ductal adenocarcinoma (PDAC) is extremely stroma‐rich. Cancer‐associated fibroblasts (CAFs) secrete proteins that activate survival and promote chemoresistance of cancer cells.
Camille Duluc, Siham Moatassim-Billah, Mounira Chalabi-Dchar, A. Perraud, R. Samain, F. Breibach, M. Gayral, P. Cordelier, M. Delisle, Marie‐Pierre Bousquet‐Dubouch, R. Tomasini, H. Schmid, M. Mathonnet, S. Pyronnet, Y. Martineau, C. Bousquet   +15 more
semanticscholar   +1 more source

Doğuşundan Günümüze İslam Felsefesi, yazar Roy Jackson, çeviren Atilla Alan (İstanbul: Litera Yayıncılık, 2017)

Cumhuriyet İlahiyat Dergisi, 2017
Değerlendirmemize konu olan “What is İslamic Philosophy?” isimli eser, “Doğuşundan Günümüze İslâm Felsefesi” adıyla Türkçe’ye çevrilmiştir. Kitabın hedef kitlesi yazar tarafından Batı’da eğitim gören ve İslam hakkında ya hiçbir şey bilmeyen ya da ...
İrfan Karadeniz
doaj  

Geno- and phenotypic characteristics and clinical outcomes of CACNA1C gene mutation associated Timothy syndrome, "cardiac only" Timothy syndrome and isolated long QT syndrome 8: A systematic review. [PDF]

Front Cardiovasc Med, 2022
Borbás J, Vámos M, Hategan L, Hanák L, Farkas N, Szakács Z, Csupor D, Tél B, Kupó P, Csányi B, Nagy V, Komócsi A, Habon T, Hegyi P, Sepp R.   +14 more
europepmc   +1 more source

Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) hyperphosphorylation is implicated in various cancers. Mammalian target of rapamycin (mTOR) targeting of canonical sites—Thr37, Thr46, Ser65, and Thr70—inhibits 4E-BP1 ...
C. Velásquez, Erdong Cheng, M. Shuda, Paula J Lee-Oesterreich, Lisa Pogge von Strandmann, M. Gritsenko, J. Jacobs, P. Moore, Yuan Chang   +8 more
semanticscholar   +1 more source