Results 51 to 60 of about 102,336 (308)

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Double Tension Band Osteosynthesis in Inter-Condylar Humeral Fractures [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Intercondylar humerus fractures are uncommon in orthopaedic practice. The treatment for the same has been described in the literature and include paragonal and orthogonal fixation by using plates.
Santosh Lakshmanrao Munde, Mohd Javed Bhatti, R.C. Siwach, Anil Gulia, Z.S.Kundu, Sanjeev Bansal, Sanjay Middha, Hemlata T Kamra   +7 more
doaj   +1 more source

GENERALISED BPS CONDITIONS [PDF]

Modern Physics Letters A, 2012
We write down two E11 invariant conditions which at low levels reproduce the known half BPS conditions for type II theories. These new conditions contain, in addition to the familiar central charges, an infinite number of further charges which are required in an underlying theory of strings and branes.
openaire   +4 more sources

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

A Cross-Sectional Study of Maternal Near Miss Events and Maternal Deaths Using the Operational Guidelines of the Government of India 2014

Gynecology Obstetrics & Reproductive Medicine
OBJECTIVE: Maternal near miss (MNM) events share many pathological and circumstantial factors with maternal mortality. Compared with maternal mortality, near-miss events are more common; thus, MNM evaluation is used to assess the quality of obstetric ...
Pinkey Lakra, Vijayata Sangwan, Jaishree Kaushik, Shivani Shivani, Sunita Siwach   +4 more
doaj   +1 more source

MIS12 Is Required for Kinetochore‐Microtubule Attachment in Oocyte Meiosis

Advanced Science, EarlyView.
A model depicting the role of MIS12 in K‐MT attachment during oocyte meiosis. The presence of MIS12 stabilizes bipolar K‐MT attachments by maintaining the function of NDC80 and its interaction with TUBB. This, in turn, promotes KNL1 assembly and subsequent SAC protein recruitment to kinetochores.
Jian Li, Chun‐Hui Zhang, Yong Wang, Cheng‐Yuan Li, Da‐Rong Wen, Xi Xia, Liang Zhou, Wei‐Ping Qian, Qing‐Yuan Sun, Chang‐Zhong Li   +9 more
wiley   +1 more source

The electrostatic view on M-theory LLM geometries [PDF]

, 2010
We describe the geometry of the R x SO(3) x SO(6) x U(1) invariant half-BPS M-theory configurations considered in LLM in terms of their electrostatic variables.
Joan Simón, Donos, Aristomenis, Aristomenis Donos, Simon, Joan   +3 more
core   +1 more source

Universally Accurate or Specifically Inadequate? Stress‐Testing General Purpose Machine Learning Interatomic Potentials

Advanced Intelligent Discovery, EarlyView.
We investigate MACE‐MP‐0 and M3GNet, two general‐purpose machine learning potentials, in materials discovery and find that both generally yield reliable predictions. At the same time, both potentials show a bias towards overstabilizing high energy metastable states. We deduce a metric to quantify when these potentials are safe to use.
Konstantin S. Jakob, Karsten Reuter, Johannes T. Margraf   +2 more
wiley   +1 more source

Digital Transformation and the Environment: An Analysis of the Impact of Digital Transactions on Carbon Emissions in Indonesia

Sriwijaya International Journal of Dynamic Economics and Business
The rapid rise in carbon emissions due to economic expansion has accelerated global warming and climate change. Amid these challenges, digital transformation in retail and financial services has emerged as a potential solution to mitigate environmental ...
Nugraha Pukuh, Hayu Fadlun Widyasthika, Shinta Mahaputri Hakim   +2 more
doaj   +1 more source