Results 71 to 80 of about 36,240 (264)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
To brace or not to brace? [PDF]
The Journal of Bone and Joint Surgery. British volume, 1985 openaire +3 more sources
Orthopaedic Journal of Sports MedicineObjectives: Postoperative rehabilitation protocols for patients undergoing proximal hamstring tendon repair have not been explored extensively. There is no consensus regarding the optimal rehab protocol and bracing strategy to protect the surgical repair.
Christian Athanasian AB +4 more
doaj +1 more source
Cell, 2018 The detachment of plant organs is highly choreographed, requiring the enzymatic dissolution of the middle lamella between cell layers at the base of the detaching organ. Now, Lee et al. demonstrate that abscission efficiency and plant health rely on the spatial confinement of enzymatic activity and mechanical features that ensure a smooth separation.
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
LifeBackground: All-day braces are predominantly used for the conservative treatment of adolescent idiopathic scoliosis (AIS). The Charleston Bending Brace is a pure nighttime brace. The aim of this study was to investigate the primary in-brace correction of
Susanne Froehlich +4 more
doaj +1 more source
مجله دانشگاه علوم پزشکی گرگان, 2021 Background and Objective: Genu varus deformity is associated with changes of lower limb muscle co-contraction and running economy. This study was done to evaluate the effect of using of brace in three different knee flexion angles on running economy and ...
Saeed Norinasab +3 more
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source