Results 91 to 100 of about 19,003 (265)

CONSERVATIVE TREATMENT OF CHILDREN WITH VERTEBRAL COMPRESSION FRACTURES OF THORACIC AND LUMBAR SPINE USING ORTHOSIS (REVIEW)

Travmatologiâ i Ortopediâ Rossii, 2016
A review of the literature on conservative and restorative treatment of children with vertebral compression fractures of thoracic and lumbar spine is presented.
I. V. Pavlov, S. V. Vissarionov, M. G. Gusev, G. A. Lein   +3 more
doaj  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Could Novel Spinal Braces with Flexibility, Robotic Components, and Individualized Design Generate Sufficient Biomechanical Treatment Efficacy in Patients with Scoliosis?

Bioengineering
Background: Patients with adolescent idiopathic scoliosis (AIS) require effective bracing to control curve progression. However, most traditional spinal braces commonly pose challenges in terms of undesired bulkiness and restricted mobility.
Chen He, Jinkun Xie, Rong Pang, Bingshan Hu, Christina Zong-Hao Ma   +4 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Evaluating the Efficiency of Milwaukee Brace on Scoliosis Deformity: A Systematic Review of Literature [PDF]

Iranian Rehabilitation Journal
Objectives: Scoliosis is a three-dimensional deformity of the spine that can be treated using various treatment approaches. The use of braces is one of the most commonly used treatment methods for controlling curve progression.
Mohammad Taghi Karimi, Majid Ansari, Morteza Faghih Jouibari   +2 more
doaj  

What are the clinical recommendations for the use of ankle braces? A scoping review

JSAMS Plus
Background: Ankle braces can be used in the treatment and prevention of lateral ankle sprains. However, there is a limited understanding and consensus about which type of brace should be used, for how long, and when to stop using ankle braces. Objective:
Tomas Megalaa, Paula R. Beckenkamp, Alycia Fong Yan, Claire E. Hiller   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source