Results 61 to 70 of about 131 (129)

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Impact of millimeter‐scale target motion on the precision of spatially fractionated radiation therapy using proton minibeams

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background While pencil beam scanning (PBS) with motion mitigation such as re‐scanning, breath hold, or gating is well established for treating moving targets in clinical practice, the precision for Spatially Fractionated Radiation Therapy (SFRT) using proton minibeams introduces presents a unique challenge.
Oxana Actis, Cristian Fernandez‐Palomo, Verdiana Trappetti, Michele Togno, Paolo Pellicioli, Dominic Leiser, David Meer, Valentin Djonov   +7 more
wiley   +1 more source

Robust optimization of catheter positions and dwell times for HDR prostate brachytherapy

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background HDR prostate brachytherapy plans are sensitive to catheter placement uncertainty, as discrepancies between planned and delivered catheter positions can degrade target coverage and increase organ at risk dose. Current inverse planning methods optimize dwell times for a fixed implant geometry and do not account for geometric ...
Joseph B. Schulz, Bryan P. Bednarz, John M. Floberg, Jordan M. Slagowski   +3 more
wiley   +1 more source

Dose modeling of superficial brachytherapy applicator geometries using multiple radioisotopes

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Superficial brachytherapy enables localized dose delivery for superficial cutaneous lesions, but conventional applicators may be limited in treating extended, irregular, or curved surfaces. Geometric constraints, gaps or overlaps between adjacent applicators, and placement‐related uncertainties can reduce dose uniformity ...
Jin Jegal, HyeoungWoo Park, Seonghee Kang, Jung‐in Kim, Chang Heon Choi, Siyong Kim   +5 more
wiley   +1 more source

Roadmap for the implementation of particle minibeam therapy

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Particle minibeam therapy (PMBT) has emerged as an advanced modality within spatially fractionated radiation therapy, using the physical properties of protons, ions, and electrons to achieve superior normal tissue sparing whilst preserving spatial dose distribution at depths that are unachievable in conventional kV or MV X‐rays.
Reem Ahmad, Oxana Actis, Adam H. Aitkenhead, Richard A. Amos, Niels Bassler, Catherine Burne, Pankaj Chaudhary, Gerd Datzmann, Umberto Deut, Fabio Di Martino, Rebecca Habgood, Simon Jolly, Emmanuel Jouglar, Eva Kasanda, Nigel Lee, Dominic Leiser, Xiangkun Li, Giuliana Milluzzo, Jessica Neubauer, Kelvin Ng Wei Siang, Hugo Palmans, Yolanda Prezado, Judith Reindl, Francesco Romano, Loris Roncali, Aikaterini Rousseti, Thomas E. Schmid, Ileana Silvestre Patallo, Frank Stephan, Anna Subiel, Edward Taylor, Annalisa Walpen, Samuel Flynn   +32 more
wiley   +1 more source

One‐Year Functional Satisfaction and Quality of Life Outcomes of Patients With a History of Radiotherapy With Artificial Urinary Sphincters

Neurourology and Urodynamics, Volume 45, Issue 7, Page 1357-1365, September 2026.
ABSTRACT Aims This study assessed how functional satisfaction and quality of life outcomes of the artificial urinary sphincter (AUS) were affected in patients who received radiation for prostate cancer. Methods A secondary analysis was conducted based on the Artificial Urinary Sphincter Clinical Outcomes (AUSCO) study, a prospective multi‐institutional
Vishu Chandrasekhar, Melissa R. Kaufman, Andrew C. Peterson, Erin L. Chaussee, Hadley M. Wood, AUSCO Collaboration Group, Benjamin N. Breyer, Bradley A. Erickson, Niels V. Johnsen, Jeremy Myers, Alex J. Vanni, Ryan Terlecki, Thomas G. Smith III, Daniel Moon Fracs, LeRoy Jones, Joshua A. Broghammer, Gerard Henry, Arthur L. Burnett, Lewis Wen Loong Chan, Brian J. Flynn, Rose Khavari, Sean Elliott   +21 more
wiley   +1 more source

Salvage Androgen Deprivation Therapy Use After Definitive Radiotherapy With vs Without Androgen Deprivation Therapy in Prostate Cancer

The Prostate, Volume 86, Issue 13, Page 1341-1351, September 15, 2026.
ABSTRACT Background For patients with unfavorable intermediate or high risk localized prostate cancer receiving definitive radiotherapy, androgen deprivation therapy reduces recurrence and improves survival but is underutilized due to toxicity concerns. Patients who forgo initial ADT may later require salvage ADT.
Jiaye Shen, Aaron J. Katz, Yahui Xie, Ronald C. Chen, Mutlay Sayan   +4 more
wiley   +1 more source

Intermediate clinical endpoints as surrogates for overall survival after salvage prostatectomy

BJU International, Volume 138, Issue 3, Page 430-437, September 2026.
Objectives To evaluate biochemical recurrence‐free survival (BRFS) and metastasis‐free survival (MFS) as potential intermediate clinical endpoints (ICEs) for overall survival (OS) in patients undergoing salvage radical prostatectomy (sRP). Patients and Methods Evaluable patients were selected from a retrospective dataset, resulting in a cohort of 879 ...
Navid Roessler, Zuzanna Nowicka, Marcin Miszczyk, Giorgio Calleris, Alessandro Dematteis, Malte W. Vetterlein, Simone Albisinni, Henk G Van Der Poel, Paul Cathcart, Giovanni E. Cacciamani, Inderbir S. Gill, Raj A. Persad, Steven Joniau, Rafael Sanchez‐Salas, Joseph A. Smith Jr, Robert Jeffrey Karnes, Mohamed E. Ahmed, Pawel Rajwa, Derya Tilki, Shahrokh F. Shariat, Paolo Gontero, Giancarlo Marra, on behalf of the Young Academic Urologists Prostate Cancer Working Party   +22 more
wiley   +1 more source

Cervical Small Cell Neuroendocrine Carcinoma Initially Detected on Cytology: Diagnostic Pitfalls and Clues

Cytopathology, Volume 37, Issue 5, Page 555-559, September 2026.
This case describes the initial detection of cervical small cell neuroendocrine carcinoma on conventional endometrial and cervicovaginal liquid‐based cytology. Given its rarity and high aggressiveness, early recognition and rapid, intensive treatment are crucial for improving patient outcomes.
Yesul Jeong
wiley   +1 more source