Results 41 to 50 of about 131 (129)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, Volume 20, Issue 9, Page 2188-2202, September 2026.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Deep learning auto‐contouring of target and organs‐at‐risk on post‐catheter implant CT images for prostate HDR brachytherapy

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Accurate delineation of the prostate and surrounding organs‐at‐risk (OARs) is essential for HDR prostate brachytherapy. Manual contouring on post‐catheter CT images is time‐consuming and prone to variability due to artifacts and anatomical deformation from the implanted brachytherapy catheters.
Eric M. Wallat, Joseph B. Schulz, John M. Floberg, Gregory Cooley, Bryan P. Bednarz, Jordan M. Slagowski   +5 more
wiley   +1 more source

Dynamic modulated arc therapy (DMAT): A time‐aware, modulation‐steered optimization framework for next‐generation radiotherapy delivery

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Conventional VMAT optimization largely treats delivery time and deliverability as emergent properties of simplified, control‐point‐centric models that often ignore finite acceleration and other dynamic limits. As modern linacs continue to increase maximum axis speeds and dose rates, there is a growing need for a planning paradigm ...
Taoran Li, Esa Kuusela, Emmi Ruokokoski, Heini Hyvönen, Jerry Jaboin, Mirko Myllykoski, Jussi Nurminen, Riku Paananen, Jarkko Peltola, Marko Rusanen, Martin Sabel, Kevin Moore, Christopher Boylan   +12 more
wiley   +1 more source

Clinical in‐vivo dosimetry for total skin electron therapy using gafchromic™ EBT4 film

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Total skin electron therapy (TSET) is a standard treatment for cutaneous T‐cell lymphoma. Due to the complex patient positioning and irregular body contours, robust in‐vivo dosimetry (IVD) is essential to verify dose uniformity. While thermoluminescent dosimeters (TLDs) are traditional standard, their utility is hindered by labor ...
Zhexuan Zhang, Lan Lu, Gregory M. M Videtic, Cherian Sheen, Ping Xia, Peng Qi   +5 more
wiley   +1 more source

Dosimetric impact of aperture‐restricted VMAT on heart dose in breast cancer treated with regional nodal irradiation

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Volumetric modulated arc therapy (VMAT) is increasingly used for breast and chest wall (CW) treatment with regional nodal irradiation (RNI) because of its ability to sculpt dose around complex target volumes. However, VMAT can increase low‐dose radiation to surrounding normal tissues and particularly increase cardiac dose.
Anh Hong Duong, Mandeep Kaur, Sunil W. Dutta, Tsegawbizu Gebru, Jacob Adams, Mark Cicchino, Reshma Jagsi, Sheela Hanasoge, Oluwatosin Kayode, Eduard Schreibmann, Hania Al‐Hallaq, Matthew Thomas, Xiaofeng Yang, Shadab Momin, Justin Roper, Kirk Luca, Jie Ding   +16 more
wiley   +1 more source

A Monte Carlo based dose verification tool for an HDR Ir‐192 brachytherapy source and its evaluation on extremity malignancies

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background TG‐43 formalism dose calculation for brachytherapy with the homogeneous water‐based assumption is widely used, which can lead to dose inaccuracy in treatment planning. Purpose Extremity malignancies are also treated with high‐dose‐rate (HDR) 192Ir interstitial brachytherapy, a treatment site that has not been specifically ...
Peixiong Li, Chi Wah Kong, Rihui Zhang, Dejun Zhou, Chenyu Huang, Tin Lok Chiu, Pak Hang Nam, Chi To Yung, Tien Yee Chang, Siu Ki Yu, Bin Yang   +10 more
wiley   +1 more source

Quantitative Cherenkov‐excited fluorescence emission dosimetry for HDR Co‐60 brachytherapy: Calibration and planar validation against TPS

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Accurate dose verification in High‐Dose‐Rate (HDR) brachytherapy presents a significant challenge due to steep dose gradients and the absence of beam collimation. Conventional quality assurance (QA) methods typically rely on point detectors or film‐based techniques, which lack the capability to provide real‐time, full‐field ...
Yagiz Yedekci, Mehmet Fazıl Enkavi, Ferah Yildiz   +2 more
wiley   +1 more source

Preclinical feasibility of EPID‐based transit dosimetry for total body irradiation

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Conventional extended‐distance total body irradiation (TBI) is commonly verified using point dosimeters, which provide limited spatial information and require additional handling during a prolonged treatment procedure. A portable charge‐coupled device (CCD)‐based electronic portal imaging device (EPID) positioned downstream of the ...
Tetsu Nakaichi, Hiroyuki Okamoto, Mitsuhiro Kon, Kazuki Takaso, Ako Aikawa, Satoshi Nakamura, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Tomonori Goka, Hiroshi Igaki   +10 more
wiley   +1 more source

A centralized hybrid model for regulatory inspection readiness in a multi‐site radiation oncology system

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background State regulatory inspections of radiation‐producing treatment equipment combine a review of quality assurance and regulatory records with direct verification of facility and safety systems. When these activities are performed entirely on‐site across multiple facilities, real‐time document retrieval can prolong visits and divert ...
Chaitanya Kalavagunta, Dustin Simonson, Mariana Guerrero   +2 more
wiley   +1 more source

Routine physics work efficacy and efficiency improvement through a shared‐duty physicist‐of‐the‐day model in a multi‐hospital radiation oncology network

Journal of Applied Clinical Medical Physics, Volume 27, Issue 9, September 2026.
Abstract Background Large multi‐hospital radiation oncology networks often rely on site‐exclusive physicist coverage models that can lead to imbalanced workload distribution, inconsistent task execution, communication fragmentation, and vulnerability to delayed or missed quality checks.
Guang‐Pei Chen, Douglas E. Prah, Eric S. Paulson   +2 more
wiley   +1 more source