Results 71 to 80 of about 180,641 (332)

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Relationship Between Heart Rate, Muscle, and Peripheral Oxygen Saturation During Dry Static Apnea

Oxygen
Background: During an apnea, oxygen depletion occurs at all tissue levels, so apnea duration is influenced by the mammalian dive reflex, which includes a bradycardia resulting in reduced cardiac oxygen consumption.
Dario Vrdoljak, Colin D. Hubbard, Geoff B. Coombs, Andrew T. Lovering, Ivan Drvis, Nikola Foretic, Joseph W. Duke, Željko Dujić   +7 more
doaj   +1 more source

The Role of Electrophysiologic Study in Device Selection for Leadless Atrial Pacing [PDF]

Texas Heart Institute Journal
The AVEIR DR (Abbott Medical) was the first dual-chamber leadless pacing system approved by the US Food and Drug Administration. Many patients with sinus node dysfunction have physiologically normal atrioventricular conduction, so an atrial-only pacing ...
Joshua R. Hirsch, MD, Jordan M. Gales, MD, Irakli Giorgberidze, MD, Hamid Afshar, MD   +3 more
doaj   +1 more source

Temporal profile and mechanisms of the prompt sympathoexcitation following coronary ligation in Wistar rats [PDF]

, 2014
Our aim was to assess the timing and mechanisms of the sympathoexcitation that occurs immediately after coronary ligation. We recorded thoracic sympathetic (tSNA) and phrenic activities, heart rate (HR) and perfusion pressure in Wistar rats subjected to ...
Abdala, Ana Paula, Mill, José Geraldo, Moraes, Davi José de Almeida, Passamani, Luciana Mesquita, Paton, Julian Francis Richmond, Sampaio, Karla Nívea   +5 more
core   +5 more sources

Excessive Ostial Stent Protrusion: Evaluation of Management Strategies and Clinical Outcomes of the Side Flap Technique

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Backgrounds Accurate stent positioning in aorto‐ostial lesions remains challenging due to complex three‐dimensional anatomy, lack of optimal fluoroscopic projections, and high rates of geographic miss. Stent overhang impairs guide catheter re‐engagement and complicates future revascularization.
Gregor Leibundgut, M. Bilal Iqbal, Claudiu Ungureanu, Anastasios Barmpas, Jasper Boeddinghaus, Teodor Buliga, Gabor G. Toth, Alexandru Achim   +7 more
wiley   +1 more source

Comparison of high-specific-activity ultratrace 123/131I-MIBG and carrier-added 123/131I-MIBG on efficacy, pharmacokinetics, and tissue distribution [PDF]

, 2010
Metaiodobenzylguanidine (MIBG) is an enzymatically stable synthetic analog of norepinephrine that when radiolabled with diagnostic ((123)I) or therapeutic ((131)I) isotopes has been shown to concentrate highly in sympathetically innervated tissues such ...
Babich, John W, Barrett, John A, Boyd, Marie, Femia, Frank J, Hillier, Shawn M, Joyal, John L, Kronauge, James F, Mairs, Robert J, Maresca, Kevin P   +8 more
core   +1 more source

Bradycardia

Definitions, 2019
Bradycardia is strictly defined in adults as a pulse rate below 60 beats per minute (bpm). However, few individuals are symptomatic unless the heart rate is below 50 bpm.
Amanda K. Brown, R. Alexis
semanticscholar   +1 more source

Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement: Incidence, Predictors, and Association With Reduced Ischemic Stroke Risk

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Development of conduction abnormalities requiring pacing after transcatheter aortic valve replacement (TAVR) is relatively common. The effects of post‐TAVR permanent pacemaker (PPM) implantation on mortality, ischemic stroke, and cardiovascular outcomes remain incompletely characterized.
Omar Saleh, Nicholas J. Valle, Shinjer Li, Saleh Mostafa, Israa Saleh, Raymond Benza, Deepak R. Talreja, Matthew R. Summers   +7 more
wiley   +1 more source

Breaking the BRASH Cycle: Early Hemodialysis Saving a Chronic Kidney Disease Patient with Severe Bradycardia

Journal of the Practice of Cardiovascular Sciences
BRASH syndrome – a clinical entity defined by bradycardia, renal failure, AV nodal blockade, shock, and hyperkalemia – represents a dangerous, self-perpetuating cycle that can rapidly lead to hemodynamic instability and multiorgan dysfunction.
Sanchit Chhabra, Sunil Kumar, Anjalee Anil Chiwhane, Utkarsh Pradeep, Gautam Bedi   +4 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of Psychological Therapies for Avoidant/Restrictive Food Intake Disorder (ARFID) in Adolescents and Adults

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The efficacy of psychological therapies for adolescents and adults with avoidant/restrictive food intake disorder (ARFID) has yet to be rigorously analyzed through systematic review or meta‐analysis. Method We identified articles from seven databases that presented psychological therapies for adolescents and adults with ARFID. First,
Copeland G. Winten, Esben Strodl, P. Evelyna Kambanis, Lynda J. Ross, Jennifer J. Thomas   +4 more
wiley   +1 more source