Results 91 to 100 of about 544,226 (346)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

High-altitude balloon platform for studying the biological response of living organisms exposed to near-space environments

Heliyon
The intangible desire to explore the mysteries of the universe has driven numerous advancements for humanity for centuries. Extraterrestrial journeys are becoming more realistic as a result of human curiosity and endeavors.
Sumeth Klomchitcharoen, Pongsakorn Wechakarn, Tanchanok Tangwattanasirikun, Noparin Smerwong, Phubase Netrapathompornkij, Thanapat Chatmeeboon, Norawit Nangsue, Vivatsathorn Thitasirivit, Krin Kaweewongsunthorn, Suvijak Piyanopharoj, Phachara Phumiprathet, Yodchanan Wongsawat   +11 more
doaj   +1 more source

Review of real brain-controlled wheelchairs [PDF]

, 2016
This paper presents a review of the state of the art regarding wheelchairs driven by a brain-computer interface (BCI). Using a brain-controlled wheelchair (BCW), disabled users could handle a wheelchair through their brain activity, granting autonomy to ...
Fernández-Rodríguez, Álvaro, Ron-Angevin, Ricardo, Velasco-Álvarez, Francisco   +2 more
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Brain computer interface advancement in neurosciences: Applications and issues

Interdisciplinary Neurosurgery, 2020
Neurosciences and Neuro-technology are continuously advancing and so individuals, society and healthcare professionals have to up date themselves with advancement. Brain computer Interface (BCI) is one such emerging technology in Neurosciences.
S. Mudgal, S. Sharma, Jitender Chaturvedi, A. Sharma   +3 more
semanticscholar   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Weighted Multi-Modal Contrastive Learning Based Hybrid Network for Alzheimer’s Disease Diagnosis

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Multiple imaging modalities and specific proteins in the cerebrospinal fluid, providing a comprehensive understanding of neurodegenerative disorders, have been widely used for computer-aided diagnosis of Alzheimer’s disease (AD).
Renping Yu, Chao Peng, Jixiang Zhu, Mingming Chen, Rui Zhang   +4 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

An Interventional Brain-Computer Interface for Long-Term EEG Collection and Motion Classification of a Quadruped Mammal

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Brain-computer interfaces (BCI) acquire electroencephalogram (EEG) signals to effectively address postoperative motor dysfunction in stroke patients by discerning their motor intentions during significant movements.
Sining Li, Gan Liu, Fan Feng, Ziqing Chang, Wenyu Li, Feng Duan   +5 more
doaj   +1 more source