Results 111 to 120 of about 183,340 (290)

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Advanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang, Yanling He, Pin Yang, Hengchang Zhang, Yueyang Tong, Lingling Jiang, Zehan Li, Meichen Yan, Xiaoheng Li, Qinghu Yang, Jing Yang, Zengqiang Yuan, Jiyan Zhang, Jinbo Cheng   +13 more
wiley   +1 more source

Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease

Revista Habanera de Ciencias Médicas
Introduction: The brain derived neurotrophic factor is a neurotrophin modulator of cognitive processes. Current studies in Alzheimer’s disease patients show alterations in biomarkers at outlying levels.
Naybí Prendes Rivero, Levis Verde Corvo, Belkis López González, Iris Dany Carmenate Rodríguez, Nibaldo B Mesa Hernández, María A Robinson Agramonte   +5 more
doaj  

Impact of Brain derived Neurotrophic factor gene polymorphism on its peripheral levels in schizophrenic patients

Journal of the Pakistan Medical Association
Objective: To determine serum levels of brain-derived neurotrophic factor and its polymorphism rs12291063 in schizophrenic patients. Method: The case-control study was conducted from January 1, 2020, to May 15, 2021, at Dr Abdul Qadeer Khan Institute ...
Irshad Bibi, Farina Hanif, Quratulain Amir, Washdev Washdev, Mohammad Furqan Bari   +4 more
doaj   +1 more source

CLINICAL AND DIAGNOSTIC VALUE OF PEROXYNITRITE AND BRAIN-DERIVED NEUROTROPHIC FACTOR IN INFANTS WITH PERINATAL HYPOXIC LESIONS OF THE CNS

Медицинский вестник Юга России, 2013
Purpose: To determine the diagnostic value of peroxynitrite and brain-derived neurotrophic factor in the genesis of perinatal lesions of the central nervous system.Materials and methods: 67 children were comprehensive survey during the first three months
A. A. Afonin, I. G. Loginova, E. A. Papsheva, S. G. Bobrova, N. A. Drukker   +4 more
doaj   +1 more source

RGS14 (414)-mediated prevention of an episodic memory loss: a study of molecular mechanism [PDF]

, 2015
A large proportion of human populations suffer memory impairments either caused by normal aging or afflicted by diverse neurological and neurodegenerative diseases. Memory enhancers and other drugs tested so far against memory loss have failed to produce
Navarro Lobato, Irene
core   +1 more source

High‐Resolution Multiplexed Sequencing of Single‐Cell Full‐length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion

Advanced Science, EarlyView.
CBTi‐seq is reported, leveraging Tn5 transposase‐mediated molecular assembly of combinatorial barcodes and UMIs for high‐resolution multiplexed sequencing of the full‐length transcriptome in single cells. This approach achieves molecular resolution by end‐to‐end sequencing, enabling reconstruction of splice variants and accurate quantification of ...
Liyong He, Kaitong Dang, Qian Sun, Wenjia Wang, Wenbo Li, Wenyi Zhang, Kaiqiang Ye, Handong Wang, Zhengyue Li, Yan Guo, Zheng Li, Chencheng Yao, Peng Li, Yan Huang, Xiangwei Zhao   +14 more
wiley   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer’s Disease (AD): A Systematic Review and Meta-Analysis [PDF]

, 2019
Ted Kheng Siang Ng, Cyrus S. H. Ho, Wilson Tam, Ee Heok Kua, Roger Ho   +4 more
openalex   +1 more source

Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]

, 2012
Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla, Sandeep Sharma, Yumei Zhuang   +2 more
core   +1 more source

Current Developments and Challenges in the Field of Biohybrid Neural Interfaces—A Scoping Review

Advanced Electronic Materials, EarlyView.
This scoping review explores recent advancements and persistent challenges in biohybrid neural interfaces, which integrate living cells with electronic devices to improve neural communication and implant biocompatibility. The article highlights key innovations, methodological diversity, and translational barriers, providing a comprehensive synthesis ...
Yi‐Lin Yu, Jameel Muzaffar, Veronica Philips, Yun‐Ju Yang, Damiano Giuseppe Barone, George G. Malliaras, Manohar Bance   +6 more
wiley   +1 more source