Results 211 to 220 of about 231,813 (388)

Somatic cell reprogramming for Parkinson's disease treatment

open access: yesIbrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Vascular endothelial cells synthesize and secrete brain‐derived neurotrophic factor [PDF]

open access: bronze, 2000
Takeshi Nakahashi   +6 more
openalex   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

open access: yesIbrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou   +6 more
wiley   +1 more source

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. [PDF]

open access: bronze, 2000
Tsutomu Nakagawa   +9 more
openalex   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

open access: yesiMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu   +8 more
wiley   +1 more source

Significant association of BDNF rs6265 G>A polymorphism with susceptibility to epilepsy: a meta-analysis

open access: yesNeuropsychiatric Disease and Treatment, 2018
Yue-Long Xu,1,* Xiu-Xiu Li,1,* Su-Jing Zhuang,1 Shi-Feng Guo,1 Jian-Ping Xiang,1 Long Wang,2 Lan Zhou,2 Bin Wu3 1Department of Neurology, Linyi Central Hospital, Linyi 276400, Shandong Province, China; 2Department of Neurology, Center for Evidence-Based
Xu Y   +7 more
doaj  

A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease [PDF]

open access: bronze, 2000
Hiroshi Kunugi   +8 more
openalex   +1 more source

Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects

open access: yesInterdisciplinary Medicine, EarlyView.
The effects of clinical therapies for spinal cord injury (SCI) are greatly limited due to poor axon regeneration. This review systematically discusses the ability of nanomaterials (NMs) to treat SCI and the mechanism underlying their therapeutic effects. The properties of NMs that are conducive to axon regeneration after SCI are outlined.
Jia Liu   +9 more
wiley   +1 more source

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