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A comparison of commercial assays quantifying mature brain-derived neurotrophic factor (mBDNF) and its precursor (pro-BDNF) in human serum. [PDF]
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Brain-Derived Neurotrophic Factor
2014Brain-derived neurotrophic factor (BDNF), is a member of neurotrophin family having roles in survival, growth and function of neurons in the central and peripheral nervous system. BDNF mRNA and protein levels have been identified in the cerebellum, hippocampus, bulbus olfactorius, spinal cord, thalamus, prefrontal cerebral cortex, hypothalamus ...
David S. Middlemas, David B. Bylund
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Brain-Derived Neurotrophic Factor in Neonatal Seizures
Pediatric Neurology, 2021Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has an extensively studied classical role in neuronal growth, differentiation, survival, and plasticity. Neurotrophic, from the Greek neuro and trophos, roughly translates as "vital nutrition for the brain." During development, BDNF and its associated receptor tyrosine ...
Brennan J. Sullivan, Shilpa D. Kadam
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Brain-derived neurotrophic factor.
Growth factors (Chur, Switzerland), 2005Since the purification of BDNF in 1982, a great deal of evidence has mounted for its central roles in brain development, physiology, and pathology. Aside from its importance in neural development and cell survival, BDNF appears essential to molecular mechanisms of synaptic plasticity.
Devin K, Binder, Helen E, Scharfman
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Brain-derived neurotrophic factor in multiple sclerosis
Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2019The review presents data on brain-derived neurotrophic factor (BDNF), its structure and functions, the effect on the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis (MS). The correlation of BDNF level with clinical manifestations of MS and the changes of its level during disease-modifying therapy is considered.
A A, Semkina +4 more
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The physiopathology of brain-derived neurotrophic factor
Physiological ReviewsBDNF is synthesized and secreted by excitatory neurons. Decades of work with animal models prepared the ground for interpreting the results of human genome analyses associating polymorphisms with memory deficits, mood disorders and dysregulation of food intake.
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Brain-derived neurotrophic factor in human platelets
Biochemical Pharmacology, 1997A sensitive, capture enzyme-linked immunosorbent assay (CELISA) has been applied to the accurate and reproducible measurement of brain-derived neurotrophic factor (BDNF) protein in normal human blood platelets, a mean concentration of 1.03 +/- 0.04 ng (SEM)/mg of platelet protein being observed.
F B, Pliego-Rivero +6 more
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The effect of brain-derived neurotrophic factor on angiogenesis
Journal of Huazhong University of Science and Technology [Medical Sciences], 2009To investigate the in vitro and in vivo proangiogenic effects of brain-derived neurotrophic factor (BDNF), human umbilical vein endothelial cells (HUVECs) were isolated and cultured in primary culture. The effect of BDNF on the proliferation of HUVECs was examined by MTT assay.
Chunyan, Sun +4 more
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Brain-derived neurotrophic factor in neurodegenerative diseases
Nature Reviews Neurology, 2009Changes in the levels and activities of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), have been described in a number of neurodegenerative disorders, including Huntington disease, Alzheimer disease and Parkinson disease. It is only in Huntington disease, however, that gain-of-function and loss-of-function experiments have ...
C. Zuccato, E. Cattaneo
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