International Journal of Advanced Scientific Technologies in Engineering and Management Sciences, 2016 R. Kamalakannan, N. Ravi Kumar
openaire +2 more sources
Brain-machine interface based on transfer-learning for detecting the appearance of obstacles during exoskeleton-assisted walking. [PDF]
Front Neurosci, 2023 Quiles V +5 more
europepmc +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Shared Control of Bimanual Robotic Limbs With a Brain-Machine Interface for Self-Feeding. [PDF]
Front Neurorobot, 2022 Handelman DA +14 more
europepmc +1 more source
Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents. [PDF]
Sci Transl Med, 2022 Sun G +7 more
europepmc +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Neuroscience-Inspired Deep Learning Brain-Machine Interface Decoder. [PDF]
Bioengineering (Basel)Ou HY +3 more
europepmc +1 more source
Training with noninvasive brain-machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study. [PDF]
Sci Rep, 2022 Nicolelis MAL +9 more
europepmc +1 more source