Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment
Advanced Science, EarlyView.This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang +7 more
wiley +1 more source
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Transitioning from global to local computational strategies during brain-machine interface learning. [PDF]
Front NeurosciBridges NR, Stickle M, Moxon KA.
europepmc +1 more source
Physiological Artifacts and the Implications for Brain-Machine-Interface Design. [PDF]
Conf Proc IEEE Int Conf Syst Man Cybern, 2020 Sorkhabi MM +3 more
europepmc +1 more source
FOCUS: A Four‐In‐One Consolidated Unison Strain Sensor with Enhanced Sensitivity
Advanced Science, EarlyView.Through a folding transformation that stacks four printed liquid metal sensors into a unified 3D orthogonal construct, FOCUS harnesses complementary bidirectional resistance responses within a Wheatstone bridge. This architecture yields fivefold sensitivity enhancement and 25 µm resolution, overcoming LM sensors’ micro‐strain limitations and enabling ...
Zimeng Wang +6 more
wiley +1 more source
Development of optically controlled "living electrodes" with long-projecting axon tracts for a synaptic brain-machine interface. [PDF]
Sci Adv, 2021 Adewole DO +10 more
europepmc +1 more source
Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes
Advanced Science, EarlyView.The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui +8 more
wiley +1 more source
A perspective on translating genomic discoveries into targets for brain-machine interface and deep brain stimulation devices. [PDF]
WIREs Mech DisValentim WL, Tylee DS, Polimanti R.
europepmc +1 more source
Traceless Regulation of Genetic Circuitry
Advanced Science, EarlyView.Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley +1 more source
Advanced Science, EarlyView.A resonant frequency engineering strategy is proposed to modulate the sensibility of piezoresistive textile‐based tactile sensor. It achieves simultaneous detection of static pressure and dynamic vibrations across an unprecedented bandwidth of 5–600 Hz, surpassing human sensation, therefore enables rapid and precise braille recognition.
Xianhong Zheng +17 more
wiley +1 more source