Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery [PDF]
, 2016 The blood-brain barrier is a highly selective anatomical and functional interface allowing a unique environment for neuro-glia networks. Blood-brain barrier dysfunction is common in most brain disorders and is associated with disease course and delayed ...
CECCANTI , MARCO +18 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis. [PDF]
, 2019 Chronic active and slowly expanding lesions with smouldering inflammation are neuropathological correlates of progressive multiple sclerosis pathology.
Arnold, Douglas L +10 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
La segregación, los guetos y la integración social urbana: mitos y claves
EURE (Santiago) - Revista Latinoamericana de Estudios Urbano Regionales, 2008 Predominan en el medio académico y político las nociones "naturalistas" sobre la segregación social del espacio en las ciudades latinoamericanas. Las desigualdades o el "clasismo", hechos fuertes y persistentes, harían de la segregación algo inevitable ...
FRANCISCO SABATINI, ISABEL BRAIN
doaj
Financial Engineering and Rationality: Experimental Evidence Based on the Monty Hall Problem [PDF]
Financial engineering often involves redefining existing financial assets to create new financial products. This paper investigates whether financial engineering can alter the environment so that irrational agents can quickly learn to be rational.
Brain Kluger, Daniel Friedman
core
The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain [PDF]
, 2012 The developing brain of Drosophila has become a useful model for studying the molecular genetic mechanisms that give rise to the complex neuronal arrays that characterize higher brains in other animals including mammals.
Bello, B. C., Kuert, P. A., Reichert, H.
core +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Frontiers in Physiology, 2018 Unlike most excitable cells, certain syncytial smooth muscle cells are known to exhibit spontaneous action potentials of varying shapes and sizes. These differences in shape are observed even in electrophysiological recordings obtained from a single cell.
Shailesh Appukuttan +5 more
doaj +1 more source
Brain mechanisms of chronic pain: critical role of translational approach
, 2021 Joana Barroso +2 more
openalex +2 more sources