Results 91 to 100 of about 6,142,833 (288)

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Stereotactic Radiosurgery Practice Patterns for Brain Metastases in the United States: A National Survey [PDF]

, 2018
Background: Stereotactic radiosurgery (SRS) has emerged as an important modality for the treatment of intracranial metastases. There are currently few established guidelines delineating indications for SRS use and fewer still regarding plan evaluation in
Bhamidipati, Deepak, Blomain, Erik S, Garg, Shivank, Guo, Jenny, Kalchman, Ingrid, Kim, MD, Hyun, McAna, John F., Shi, Wenyin   +7 more
core   +2 more sources

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Brain networks under attack : robustness properties and the impact of lesions [PDF]

, 2016
A growing number of studies approach the brain as a complex network, the so-called ‘connectome’. Adopting this framework, we examine what types or extent of damage the brain can withstand—referred to as network ‘robustness’—and conversely, which kind of ...
Aerts, Hannelore, Caeyenberghs, Karen, Fias, Wim, Marinazzo, Daniele   +3 more
core   +2 more sources

Physiological sharp wave-ripples and interictal events in vitro: What’s the difference? [PDF]

, 2014
Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features.
Freund, Tamás, Gulyás, Attila, Karlócai, R. Mária, Kohus, Zsolt, Káli, Szabolcs, Máté, Zoltán, Szabó, Gábor, Ulbert, István   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A study of the means of increasing the dynamic range of visual simulation by means of a flying-spot scanner Final report [PDF]

Increasing dynamic range of visual simulation for pilots using flying spot ...
Brain, A. E.
core   +1 more source

The degraded concept representation system in semantic dementia:damage to pan-modal hub, then visual spoke [PDF]

, 2012
The core clinical feature of semantic dementia is a progressive yet selective degradation of conceptual knowledge. Understanding the cognitive and neuroanatomical basis for this deficit is a key challenge for both clinical and basic science.
Acosta-Cabronero, Antonucci, Baayen, Barsalou, Beauchamp, Binder, Binney, Bonner, Bonner, Bozeat, Bozeat, Breedin, Bright, Buxbaum, Capitani, Caramazza, Chao, Coltheart, Farah, Folstein, Funnell, Gainotti, Galantucci, Galton, Garrard, Goldberg, Goll, Gorno-Tempini, Hodges, Hodges, Hoffman, Hoffman, Hoffman, Ishibashi, Jefferies, Jefferies, Jefferies, Kellenbach, Kellenbach, Kiefer, Kiefer, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lambon Ralph, Lewis, Luzzi, Macoir, Marinkovic, Martin, Martin, Matthew A. Lambon Ralph, Mayberry, Mion, Nestor, Papagno, Patterson, Patterson, Paul Hoffman, Pexman, Piwnica-Worms, Plaut, Pobric, Pobric, Pobric, Pulvermuller, Raven, Rogers, Rogers, Rogers, Rohrer, Roy W. Jones, Sharp, Snodgrass, Thompson-Schill, Tyler, Van Dam, Vandenberghe, Visser, Visser, Warrington, Warrington, Warrington, Wechsler, Woollams, Woollams, Yi   +88 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Financial Engineering and Rationality: Experimental Evidence Based on the Monty Hall Problem [PDF]

Financial engineering often involves redefining existing financial assets to create new financial products. This paper investigates whether financial engineering can alter the environment so that irrational agents can quickly learn to be rational.
Brain Kluger, Daniel Friedman
core