Results 91 to 100 of about 8,779,803 (385)
Brain networks under attack : robustness properties and the impact of lesions [PDF]
, 2016 A growing number of studies approach the brain as a complex network, the so-called ‘connectome’. Adopting this framework, we examine what types or extent of damage the brain can withstand—referred to as network ‘robustness’—and conversely, which kind of ...
Aerts, Hannelore +3 more
core +2 more sources
“Not” in the brain and behavior [PDF]
PLOS BiologyNegation is key for cognition but has no physical basis, raising questions about its neural origins. A new study in PLOS Biology on the negation of scalar adjectives shows that negation acts in part by altering the response to the adjective it negates.
Cas W. Coopmans +2 more
openaire +4 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Revista MethodoINTRODUCCCION: El síndrome de Jacobsen (deleción 11q) es una condición genética poco común con una prevalencia estimada de 1:100.000 nacimientos, una proporción mujer/hombre de 2:1.
Brain Lascano L C +2 more
doaj +1 more source
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Frontiers in Endocrinology, 2020 A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions.
Ygor Parladore Silva +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Physiological sharp wave-ripples and interictal events in vitro: What’s the difference? [PDF]
, 2014 Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features.
Freund, Tamás +7 more
core +1 more source
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source
Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis. [PDF]
, 2019 Chronic active and slowly expanding lesions with smouldering inflammation are neuropathological correlates of progressive multiple sclerosis pathology.
Arnold, Douglas L +10 more
core +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source