Results 21 to 30 of about 2,890,246 (202)

Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age [PDF]

, 2019
Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural ...
Babor, Boecker-Schlier, Brain Development Cooperative Group, Brenhouse, Casanova, Dager, Durston, Goddings, Goodkind, Goodman, Heinz, Jacobus, Kievit, Koob, Kühn, Kühn, Little, Madhyastha, McArdle, Muthen, Nees, Norman, Olsen, Ostby, Raz, Ritchie, Schumann, Squeglia, Squeglia, Whelan   +29 more
core   +1 more source

RNA sequencing dataset describing transcriptional changes in cervical dorsal root ganglia after bilateral pyramidotomy and forelimb intramuscular gene therapy with an adeno-associated viral vector encoding human neurotrophin-3

Data in Brief, 2018
Unilateral or bilateral corticospinal tract injury in the medullary pyramids in adult rats causes anatomical and physiological changes in proprioceptive neurons projecting to the cervical spinal cord accompanied by hyperreflexia and abnormal behavioural ...
Claudia Kathe, Lawrence D.F. Moon
doaj   +1 more source

Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy. [PDF]

, 2017
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits.
Barkovich, A James, Ferriero, Donna M, Gano, Dawn, Glass, Hannah C, Gorno-Tempini, Maria Luisa, Kim, Hosung, Mandelli, Maria Luisa, Rogers, Elizabeth E, Shapiro, Kevin A, Xu, Duan   +9 more
core   +2 more sources

Brain Aging and Gut–Brain Axis [PDF]

Nutrients, 2019
In the last decade, the microbiome in general and the gut microbiome in particular have been associated not only to brain development and function, but also to the pathophysiology of brain aging and to neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), depression, or multiple sclerosis (MS) [...]
openaire   +2 more sources

MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death

Neurobiology of Disease, 2015
The activation of microglia after spinal cord injury (SCI) contributes to secondary damage by producing pro-inflammatory cytokines and mediators, leading to cell death of oligodendrocytes and neurons.
Jee Y. Lee, Hae Y. Choi, Tae Y. Yune
doaj   +1 more source

Disconnected aging: cerebral white matter integrity and age-related differences in cognition. [PDF]

, 2014
Cognition arises as a result of coordinated processing among distributed brain regions and disruptions to communication within these neural networks can result in cognitive dysfunction.
Bennett, IJ, Madden, DJ
core   +1 more source

Risk Prediction of Alzheimer’s Disease Conversion in Mild Cognitive Impaired Population Based on Brain Age Estimation

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2023
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the world. To reduce the incidence of AD, it’s essential to quantify the AD conversion risk of mild cognitive impaired (MCI) individuals.
Weijia Liu, Qunxi Dong, Shuting Sun, Jian Shen, Kun Qian, Bin Hu   +5 more
doaj   +1 more source

From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]

, 2018
Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R., C., Squarcina, Carli, De, F., Brambilla, F., Sirgiovanni, Fumagalli, M., I., Giorda, L., Pozzoli, Montirosso, Rosario, Mosca, F., P., Dessimone, Provenzi, L., R., Cinnante, U., Triulzi   +13 more
core   +1 more source

Pathways and Patterns of Cell Loss in Verified Alzheimer’s Disease: A Factor and Cluster Analysis of Clinico-Pathological Subgroups

Behavioural Neurology, 1994
Thirty-seven patients with neuropathologically verified Alzheimer's disease (AD) have been studied prospectively. A principal components analysis of neuron numbers in cortical and subcortical areas revealed two variables: Variable I with high loadings ...
H. Förstl, R. Levy, A. Burns, P. Luthert, N. Cairns   +4 more
doaj   +1 more source

Jmjd3 mediates blood–spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions

Neurobiology of Disease, 2016
The disruption of the blood–spinal cord barrier (BSCB) by matrix metalloprotease (MMP) activation is a detrimental event that leads to blood cell infiltration, inflammation, and apoptosis, thereby contributing to permanent neurological disability after ...
Jee Y. Lee, Won H. Na, Hae Y. Choi, Kwang H. Lee, Bong G. Ju, Tae Y. Yune   +5 more
doaj   +1 more source