Results 41 to 50 of about 2,910,945 (298)

Gallic acid attenuates blood-spinal cord barrier disruption by inhibiting Jmjd3 expression and activation after spinal cord injury

Neurobiology of Disease, 2020
After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption results in secondary injury including apoptotic cell death of neurons and oligodendrocytes, thereby leads to permanent neurological deficits.
Chan Sol Park, Jee Youn Lee, Hae Young Choi, Kwanghyun Lee, Yeonju Heo, Bong Gun Ju, Hae-Young Park Choo, Tae Young Yune   +7 more
doaj   +1 more source

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources

Imatinib prevents blood-spinal cord barrier disruption by inhibiting PDGFR-mediated JMJD3 expression and activation after spinal cord injury

Fluids and Barriers of the CNS
Background After a spinal cord injury (SCI), disruption of the blood-spinal cord barrier (BSCB) leads to secondary injuries, including inflammatory responses and apoptotic cell death, ultimately causing permanent neurological deficits.
Chan Sol Park, Jee Youn Lee, Tae Young Yune   +2 more
doaj   +1 more source

Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants

Frontiers in Psychology, 2023
Brain age refers to age predicted by brain features. Brain age has previously been associated with various health and disease outcomes and suggested as a potential biomarker of general health.
Max Korbmacher, Max Korbmacher, Max Korbmacher, Tiril P. Gurholt, Ann-Marie G. de Lange, Ann-Marie G. de Lange, Ann-Marie G. de Lange, Dennis van der Meer, Dennis van der Meer, Dani Beck, Dani Beck, Dani Beck, Eli Eikefjord, Eli Eikefjord, Arvid Lundervold, Arvid Lundervold, Arvid Lundervold, Arvid Lundervold, Ole A. Andreassen, Ole A. Andreassen, Lars T. Westlye, Lars T. Westlye, Lars T. Westlye, Ivan I. Maximov, Ivan I. Maximov   +24 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Carvacrol improves neurological function by inhibiting TRPM7-mediated BBB disruption and hemorrhage after TBI

Acta Neuropathologica Communications
Traumatic brain injury (TBI) triggers a cascade of secondary pathophysiological events, including blood-brain barrier (BBB) disruption, intracerebral hemorrhage, neuroinflammation, neuronal death, and persistent neurological deficits.
Chan Sol Park, Jee Youn Lee, Youngmin Bu, Tae Young Yune   +3 more
doaj   +1 more source

Persistent Non-pharmacological Pain Management and Brain-Predicted Age Differences in Middle-Aged and Older Adults With Chronic Knee Pain

Frontiers in Pain Research, 2022
Chronic pain has been associated with changes in pain-related brain structure and function, including advanced brain aging. Non-pharmacological pain management is central to effective pain management.
Alisa J. Johnson, Alisa J. Johnson, James Cole, James Cole, Roger B. Fillingim, Roger B. Fillingim, Yenisel Cruz-Almeida, Yenisel Cruz-Almeida   +7 more
doaj   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

A latent class analysis of parental bipolar disorder: examining associations with offspring psychopathology [PDF]

, 2015
Bipolar disorder (BD) is highly heterogeneous, and course variations are associated with patient outcomes. This diagnostic complexity challenges identification of patients in greatest need of intervention.
Freed, Rachel D., Henin, Aude, Nierenberg, Andrew A., Otto, Michael W., Tompson, Martha C.   +4 more
core   +1 more source