Results 51 to 60 of about 2,910,945 (298)

Aging of the Brain [PDF]

, 2013
An increasing number of persons live for nine or more decades and enjoy the benefits of a well-functioning brain until the end of their life. In that respect, the cognitive performance in later life and the quality maintenance of the brain are amazing biological phenomena.
Luiten, P., Nyakas, C., Eisel, U., van der Zee, E.   +3 more
openaire   +4 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Deep grey matter volumetry as a function of age using a semi-automatic qMRI algorithm [PDF]

, 2016
Quantitative Magnetic Resonance has become more and more accepted for clinical trial in many fields. This technique not only can generate qMRI maps (such as T1/T2/PD) but also can be used for further postprocessing including segmentation of brain and ...
Yu, Hailong
core   +1 more source

Traumatic brain injury: Age at injury influences dementia risk after TBI [PDF]

, 2015
Traumatic brain injury (TBI) is increasingly recognized as a risk factor for dementia. New data provide further support for this association and demonstrate the influence of age at injury and injury severity on dementia risk after TBI, revealing that ...
AC McKee, CW Hukkelhoven, DH Smith, GM Savva, M Susman, RC Gardner, S Fleminger, VE Johnson, VE Johnson, Victoria E. Johnson, William Stewart   +10 more
core   +1 more source

A Neuroimaging Signature of Cognitive Aging from Whole‐Brain Functional Connectivity

Advanced Science, 2022
Cognitive decline is amongst one of the most commonly reported complaints during normal aging. Despite evidence that age and cognition are linked with similar neural correlates, no previous studies have directly ascertained how these two constructs ...
Rongtao Jiang, Dustin Scheinost, Nianming Zuo, Jing Wu, Shile Qi, Qinghao Liang, Dongmei Zhi, Na Luo, Young‐Chul Chung, Sha Liu, Yong Xu, Jing Sui, Vince Calhoun   +12 more
doaj   +1 more source

Predicting Brain Age at Slice Level: Convolutional Neural Networks and Consequences for Interpretability

Frontiers in Psychiatry, 2021
Problem: Chronological aging in later life is associated with brain degeneration processes and increased risk for disease such as stroke and dementia. With a worldwide tendency of aging populations and increased longevity, mental health, and psychiatric ...
Pedro L. Ballester, Laura Tomaz da Silva, Matheus Marcon, Matheus Marcon, Nathalia Bianchini Esper, Nathalia Bianchini Esper, Benicio N. Frey, Benicio N. Frey, Augusto Buchweitz, Augusto Buchweitz, Augusto Buchweitz, Felipe Meneguzzi   +11 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Longitudinal Analysis of Brain-Predicted Age in Amnestic and Non-amnestic Sporadic Early-Onset Alzheimer's Disease

Frontiers in Aging Neuroscience, 2021
Objective: Predicted age difference (PAD) is a score computed by subtracting chronological age from “brain” age, which is estimated using neuroimaging data.
Morgan Gautherot, Grégory Kuchcinski, Grégory Kuchcinski, Grégory Kuchcinski, Cécile Bordier, Adeline Rollin Sillaire, Adeline Rollin Sillaire, Xavier Delbeuck, Mélanie Leroy, Mélanie Leroy, Xavier Leclerc, Xavier Leclerc, Xavier Leclerc, Jean-Pierre Pruvo, Jean-Pierre Pruvo, Jean-Pierre Pruvo, Florence Pasquier, Florence Pasquier, Florence Pasquier, Renaud Lopes, Renaud Lopes   +20 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

How is your mind-set? Proof of concept for the measurement of the level of emotional development [PDF]

, 2019
Background In persons with intellectual and developmental disabilities, not only cognitive brain functions, but also socio-emotional processing networks may be impaired.
Birkner, Joana, Böhm, Julia, Heinrich, Manuel, Roth, Gerhard, Sappok, Tanja   +4 more
core   +1 more source