Results 41 to 50 of about 2,890,246 (202)

Gallic acid attenuates blood-spinal cord barrier disruption by inhibiting Jmjd3 expression and activation after spinal cord injury

Neurobiology of Disease, 2020
After spinal cord injury (SCI), blood-spinal cord barrier (BSCB) disruption results in secondary injury including apoptotic cell death of neurons and oligodendrocytes, thereby leads to permanent neurological deficits.
Chan Sol Park, Jee Youn Lee, Hae Young Choi, Kwanghyun Lee, Yeonju Heo, Bong Gun Ju, Hae-Young Park Choo, Tae Young Yune   +7 more
doaj   +1 more source

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Imatinib prevents blood-spinal cord barrier disruption by inhibiting PDGFR-mediated JMJD3 expression and activation after spinal cord injury

Fluids and Barriers of the CNS
Background After a spinal cord injury (SCI), disruption of the blood-spinal cord barrier (BSCB) leads to secondary injuries, including inflammatory responses and apoptotic cell death, ultimately causing permanent neurological deficits.
Chan Sol Park, Jee Youn Lee, Tae Young Yune   +2 more
doaj   +1 more source

Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participants

Frontiers in Psychology, 2023
Brain age refers to age predicted by brain features. Brain age has previously been associated with various health and disease outcomes and suggested as a potential biomarker of general health.
Max Korbmacher, Max Korbmacher, Max Korbmacher, Tiril P. Gurholt, Ann-Marie G. de Lange, Ann-Marie G. de Lange, Ann-Marie G. de Lange, Dennis van der Meer, Dennis van der Meer, Dani Beck, Dani Beck, Dani Beck, Eli Eikefjord, Eli Eikefjord, Arvid Lundervold, Arvid Lundervold, Arvid Lundervold, Arvid Lundervold, Ole A. Andreassen, Ole A. Andreassen, Lars T. Westlye, Lars T. Westlye, Lars T. Westlye, Ivan I. Maximov, Ivan I. Maximov   +24 more
doaj   +1 more source

A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]

, 2012
Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian, Lawford, Bruce, Morris, Phillip, Swagell, Christopher, Voisey, Joanne, Young, Ross   +5 more
core   +2 more sources

Carvacrol improves neurological function by inhibiting TRPM7-mediated BBB disruption and hemorrhage after TBI

Acta Neuropathologica Communications
Traumatic brain injury (TBI) triggers a cascade of secondary pathophysiological events, including blood-brain barrier (BBB) disruption, intracerebral hemorrhage, neuroinflammation, neuronal death, and persistent neurological deficits.
Chan Sol Park, Jee Youn Lee, Youngmin Bu, Tae Young Yune   +3 more
doaj   +1 more source

Persistent Non-pharmacological Pain Management and Brain-Predicted Age Differences in Middle-Aged and Older Adults With Chronic Knee Pain

Frontiers in Pain Research, 2022
Chronic pain has been associated with changes in pain-related brain structure and function, including advanced brain aging. Non-pharmacological pain management is central to effective pain management.
Alisa J. Johnson, Alisa J. Johnson, James Cole, James Cole, Roger B. Fillingim, Roger B. Fillingim, Yenisel Cruz-Almeida, Yenisel Cruz-Almeida   +7 more
doaj   +1 more source

How is your mind-set? Proof of concept for the measurement of the level of emotional development [PDF]

, 2019
Background In persons with intellectual and developmental disabilities, not only cognitive brain functions, but also socio-emotional processing networks may be impaired.
Birkner, Joana, Böhm, Julia, Heinrich, Manuel, Roth, Gerhard, Sappok, Tanja   +4 more
core   +1 more source

Enlarged cerebrospinal fluid spaces in opiate-dependent male patients: A stereological CT study [PDF]

, 1998
Computed tomography was performed in 9 male patients with a diagnosis of opiate dependence and in 9 age-matched psychiatric controls (neurotic depression).
Broich, Karl, Brömel, Thomas, Danos, Peter, Kasper, Siegfried, Krappel, Christian, Möller, Hans-Jürgen, Solymosi, Lazslo, Van Roos, Dirk   +7 more
core   +1 more source

Aging of the Brain [PDF]

, 2013
An increasing number of persons live for nine or more decades and enjoy the benefits of a well-functioning brain until the end of their life. In that respect, the cognitive performance in later life and the quality maintenance of the brain are amazing biological phenomena.
Luiten, P., Nyakas, C., Eisel, U., van der Zee, E.   +3 more
openaire   +4 more sources