Results 161 to 170 of about 2,163,819 (261)

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Siibra: a software tool suite for realizing a Multilevel Human Brain Atlas from complex data resources. [PDF]

Nat Methods
Dickscheid T, Gui X, Simsek AN, Schiffer C, Mangin JF, Leprince Y, Jirsa V, Bjaalie JG, Leergaard TB, Bludau S, Amunts K.   +10 more
europepmc   +1 more source

AllenDigger, a Tool for Spatial Expression Data Visualization, Spatial Heterogeneity Delineation, and Single-Cell Registration Based on the Allen Brain Atlas. [PDF]

J Phys Chem A, 2023
Wang M, Zhuo L, Ma W, Wu Q, Zhuo Y, Wang X.   +5 more
europepmc   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

scBrainScope: cross-species multidimensional brain atlas. [PDF]

Nucleic Acids Res
Qin S, Yang Y, Wang H, Li M, Deng Y, Chen Y, Li C, Peng L, Xu L, Qiu X, Guan Y, Wang S, He Y, Wang X, Ma Y, Huang L, Chen D.   +16 more
europepmc   +1 more source

A micro-CT-based standard brain atlas of the bumblebee. [PDF]

Cell Tissue Res, 2021
Rother L, Kraft N, Smith DB, El Jundi B, Gill RJ, Pfeiffer K.   +5 more
europepmc   +1 more source

ATLAS "Splash event" 2008

, 2014
"Splash events": As the LHC was being tuned up on 10 September 2008, beam was initially directed at beam collimators just outside the detector, so that a splash of particles would fill much of the detector allowing ATLAS experimenters to prepare the ...
ATLAS, Experiment
core  

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

A 3D amphioxus brain atlas illuminates the blueprint of the ancestral chordate brain and highlights unique vertebrate innovations. [PDF]

Sci Adv
Lin CY, Hsu WH, Lu MJ, Chen YH, Li KL, Chen YC, Su YH, Chou SJ, Yu JK.   +8 more
europepmc   +1 more source

A brain atlas of axonal and synaptic delays based on modelling of cortico-cortical evoked potentials. [PDF]

Brain, 2022
Lemaréchal JD, Jedynak M, Trebaul L, Boyer A, Tadel F, Bhattacharjee M, Deman P, Tuyisenge V, Ayoubian L, Hugues E, Chanteloup-Forêt B, Saubat C, Zouglech R, Reyes Mejia GC, Tourbier S, Hagmann P, Adam C, Barba C, Bartolomei F, Blauwblomme T, Curot J, Dubeau F, Francione S, Garcés M, Hirsch E, Landré E, Liu S, Maillard L, Metsähonkala EL, Mindruta I, Nica A, Pail M, Petrescu AM, Rheims S, Rocamora R, Schulze-Bonhage A, Szurhaj W, Taussig D, Valentin A, Wang H, Kahane P, George N, David O, F-TRACT consortium.   +43 more
europepmc   +1 more source