Results 91 to 100 of about 1,727,506 (349)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

S100B Protein as a Post-traumatic Biomarker for Prediction of Brain Death in Association With Patient Outcomes [PDF]

, 2013
Background: S100B is a calcium-binding protein, belonging to the S100 family proteins which are characterized by their high solubility and, currently, comprises 21 members which are expressed in a cell-specific manner.
Mahdkhah, A., Panahi, F., Shakeri, M.
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Brain Death and Its Prediction in Out-of-Hospital Cardiac Arrest Patients Treated with Targeted Temperature Management [PDF]

, 2022
Hwan Song, Sang Hoon Oh, Hye Rim Woo, on behalf of CROWN Investigators   +3 more
openalex   +1 more source

Conjugate coupling induced symmetry breaking and quenched oscillations

, 2018
Spontaneous symmetry breaking (SSB) is essential and plays a vital role many natural phenomena, including the formation of Turing pattern in organisms and complex patterns in brain dynamics.
Chandrasekar, V. K., Lakshmanan, M., Ponrasu, K., Sathiyadevi, K.   +3 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Respiratory‐like movements during an apnea test

Acute Medicine & Surgery
Background Despite the possible occurrence of spontaneous movements during an apnea test, respiratory‐like movements are rare. Case Presentation A 51‐year‐old man was transferred to our hospital when a sudden disturbance of consciousness developed into ...
Shinichi Kida, Isao Nagata, Tetsuhiro Takei, Kazuhiro Yoshizawa, Taketo Suzuki, Hiroyuki Yamada, Yusuke Nakayama   +6 more
doaj   +1 more source

Computed Tomography Angiography as Ancillary Testing for Death Determination by Neurologic Criteria: A Technical Review

Tomography
The determination of death by neurological criteria (DNC) stands as a pivotal aspect of medical practice, involving a nuanced clinical diagnosis. Typically, it comes into play following a devastating brain injury, signalling the irreversible cessation of
Abanoub Aziz Rizk, Jai Shankar
doaj   +1 more source

Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model

Frontiers in Immunology, 2019
Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic instability, hormonal changes and immunological activation ...
Neeltina M. Jager, Judith E. van Zanden, Marta Subías, Marta Subías, Henri G. D. Leuvenink, Mohamed R. Daha, Mohamed R. Daha, Santiago Rodríguez de Córdoba, Santiago Rodríguez de Córdoba, Felix Poppelaars, Marc A. Seelen   +10 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source