Results 71 to 80 of about 1,717,350 (303)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The usefulness of end-tidal carbon dioxide monitoring during apnea test in brain-dead patients [PDF]
Korean Journal of Anesthesiology, 2014 BackgroundThe apnea test (AT) is essential to confirming the diagnosis of brain death, but critical complications can occur if the AT is maintained over a long period. To minimize the AT period, we used end-tidal carbon dioxide (ETCO2) monitoring because
Ha Yeon Kim +3 more
doaj +1 more source
Knowledge and attitudes toward brain death and organ donation in Bojnurd [PDF]
, 2017 دانش و نگرش مردم شهر بجنورد (خراسان شمالی) در باره مرگ مغزی و اهدای ...
Hejazi, Sima Sadat +2 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cardiotocographic and Doppler Ultrasonographic Findings in a Fetus with Brain Death Syndrome
Taiwanese Journal of Obstetrics & Gynecology, 2006 Objective: The diagnosis of brain death syndrome by cardiotocography (CTG) and Doppler ultrasonography (US) is reported in a fetus at 35 weeks of gestation.
Yi-Ting Chen +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla +2 more
core +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Losing brain networks during death
Interdisciplinary MedicineDeath represents the end of all living organisms. The pattern of brain activity disappearance following death, however, has not been fully elucidated.
Han Li +22 more
doaj +1 more source
Hypernatremia in brain‐dead patients
Brain and Behavior, 2022 Objectives Hypernatremia often occurs in patients with brain death. This study summarizes its characteristics. Methods We recorded 57 patient's highest blood sodium value, as well as daily NT‐proBNP, blood creatinine, and urine output.
Weixin Guo +5 more
doaj +1 more source