Results 61 to 70 of about 793,658 (251)

Brain Death in Islamic Jurisprudence

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016
BACKGROUND AND OBJECTIVE: In today's world, Islamic jurisprudence encounters  new issues. One of the areas where jurisprudence gets involved is the issues concerned with brain death, whether brain death in jurisprudence and Islamic law is considered the ...
A Nikzad, GA Jorsaraei
doaj  

The Importance of Caring for Brain Death Patients Candidate for Organ Donation: A Qualitative Study

نشریه پرستاری ایران, 2022
Background & Aims: Caring for patients with the diagnosis of brain death is one of the heaviest duties for nurses. The importance of organ donation is one of the biggest challenges of nursing in the intensive care unit. This qualitative research aimed to
Hamideh Yazdimoghaddam, Zahra Sadat Manzari, Abas Heydari, Esa Mohammadi, Ibrahim Khaleghi   +4 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Brain based criteria for death in the light of the Aristotelian-Scholastic anthropology

Scientia et Fides, 2018
In 1968 the authors of the so-called Harvard Report, proposed the recognition of an irreversible coma as a new criterion for death. The proposal was accepted by the medical, legal, religious and political circles in spite of the lack of any explanation ...
Jacek Maria Norkowski
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Respiratory‐like movements during an apnea test

Acute Medicine & Surgery
Background Despite the possible occurrence of spontaneous movements during an apnea test, respiratory‐like movements are rare. Case Presentation A 51‐year‐old man was transferred to our hospital when a sudden disturbance of consciousness developed into ...
Shinichi Kida, Isao Nagata, Tetsuhiro Takei, Kazuhiro Yoshizawa, Taketo Suzuki, Hiroyuki Yamada, Yusuke Nakayama   +6 more
doaj   +1 more source

Computed Tomography Angiography as Ancillary Testing for Death Determination by Neurologic Criteria: A Technical Review

Tomography
The determination of death by neurological criteria (DNC) stands as a pivotal aspect of medical practice, involving a nuanced clinical diagnosis. Typically, it comes into play following a devastating brain injury, signalling the irreversible cessation of
Abanoub Aziz Rizk, Jai Shankar
doaj   +1 more source

Blocking Complement Factor B Activation Reduces Renal Injury and Inflammation in a Rat Brain Death Model

Frontiers in Immunology, 2019
Introduction: The majority of kidneys used for transplantation are retrieved from brain-dead organ donors. In brain death, the irreversible loss of brain functions results in hemodynamic instability, hormonal changes and immunological activation ...
Neeltina M. Jager, Judith E. van Zanden, Marta Subías, Marta Subías, Henri G. D. Leuvenink, Mohamed R. Daha, Mohamed R. Daha, Santiago Rodríguez de Córdoba, Santiago Rodríguez de Córdoba, Felix Poppelaars, Marc A. Seelen   +10 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source