Results 61 to 70 of about 5,759,332 (341)

Brain death and marginal grafts in liver transplantation

Cell Death and Disease, 2015
It is well known that most organs for transplantation are currently procured from brain-dead donors; however, the presence of brain death is an important risk factor in liver transplantation.
M. Jiménez-Castro, J. Gracia‐Sancho, C. Peralta   +2 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Biological Principles in Self-Organization of Young Brain - Viewed from Kohonen Model [PDF]

, 2006
Variants of the Kohonen model are proposed to study biological principles of self-organization in a model of young brain. We suggest a function to measure aquired knowledge and use it to auto-adapt the topology of neuronal connectivity, yielding ...
A. De Angelis, B. G. Sidharth, F. Honsell, H. Kröger, K. Sreenivasan, M. Parizeau, O. Mansutti, T. Pallaver   +7 more
core   +2 more sources

The Importance of Caring for Brain Death Patients Candidate for Organ Donation: A Qualitative Study

نشریه پرستاری ایران, 2022
Background & Aims: Caring for patients with the diagnosis of brain death is one of the heaviest duties for nurses. The importance of organ donation is one of the biggest challenges of nursing in the intensive care unit. This qualitative research aimed to
Hamideh Yazdimoghaddam, Zahra Sadat Manzari, Abas Heydari, Esa Mohammadi, Ibrahim Khaleghi   +4 more
doaj  

Brain based criteria for death in the light of the Aristotelian-Scholastic anthropology

Scientia et Fides, 2018
In 1968 the authors of the so-called Harvard Report, proposed the recognition of an irreversible coma as a new criterion for death. The proposal was accepted by the medical, legal, religious and political circles in spite of the lack of any explanation ...
Jacek Maria Norkowski
doaj   +1 more source

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury*

Critical Care Medicine, 2019
Objectives: Traumatic brain injury triggers multiple cell death pathways, possibly including ferroptosis—a recently described cell death pathway that results from accumulation of 15-lipoxygenase–mediated lipid oxidation products, specifically oxidized ...
Elizabeth M. Kenny, Emin Fidan, Qin Yang, T. Anthonymuthu, L. New, Elizabeth A. Meyer, Hong Wang, P. Kochanek, C. Dixon, V. Kagan, H. Bayır   +10 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2

Molecular Brain, 2019
Ferroptosis, a newly discovered form of iron-dependent regulated cell death, has been implicated in traumatic brain injury (TBI). MiR-212-5p has previously been reported to be downregulated in extracellular vesicles following TBI.
Xiao Xiao, Youjing Jiang, Weibo Liang, Yanyun Wang, Shuqiang Cao, He Yan, Linbo Gao, Lin Zhang   +7 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo

Development, 2019
Moderate or severe traumatic brain injury (TBI) causes widespread neuronal cell death. Microglia, the resident macrophages of the brain, react to injury by migrating to the lesion site, where they phagocytose cellular debris.
Chiara M S Herzog, Laura Pons Garcia, Marcus Keatinge, David Greenald, Christian Moritz, F. Peri, L. Herrgen   +6 more
semanticscholar   +1 more source