Results 61 to 70 of about 1,727,506 (349)
Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]
, 2013 Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J. +5 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Losing brain networks during death
Interdisciplinary MedicineDeath represents the end of all living organisms. The pattern of brain activity disappearance following death, however, has not been fully elucidated.
Han Li +22 more
doaj +1 more source
Deceased organ donation of foreign nationals in India
Indian Journal of Transplantation, 2019 Inward foreign tourism in India is on the rise and the tourists are equally at risk of fatal road accidents and stroke leading to brain death. This provides an opportunity for organ donation; however, no guidelines are available on how to proceed in such
Pallavi Kumar +9 more
doaj +1 more source
Reply to Melissa Moschella [PDF]
, 2016 Professor Moschella begins by discussing confusions in the brain death debate surrounding the use of the concepts of “integration” and “wholeness.” Some scholars, she says, such as Alan Shewmon, take the presence of biological integration as an ...
Brugger, E
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Analiza i Egzystencja, 2018 DONATION AFTER CIRCULATORY DETERMINATION OF DEATH. ABOUT THE PRECEDENCE OF NEUROLOGICAL CRITERION OF DEATH OVER CIRCULATORY CRITERION – PHILOSOPHICAL ISSUES Summary This two-part article concerns with bioethical issues associated with organ donation
Piotr Nowak
doaj +1 more source
On Evolution of God-Seeking Mind: An Inquiry Into Why Natural Selection Would Favor Imagination and Distortion of Sensory Experience [PDF]
, 2002 The earliest known products of human imagination appear to express a primordial concern and struggle with thoughts of dying and of death and mortality.
Montell, Conrad
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