Results 111 to 120 of about 13,615,341 (366)
Blood-Brain Barrier: From Physiology to Disease and Back.
Physiological Reviews, 2019 The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly ...
Melanie D. Sweeney +4 more
semanticscholar +1 more source
Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study.
Brain : a journal of neurology, 2020 Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-synuclein aggregates, which may propagate from cell-to-cell in a prion-like manner. However, it remains uncertain where the initial α-synuclein aggregates originate.
Jacob Horsager +20 more
semanticscholar +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Magnetochemistry, 2019 Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabolism. Under normal physiological conditions, oxidative damage is prevented by the regulation of ROS by the antioxidant network. However, increased ROS and
Hirotada G. Fujii +2 more
doaj +1 more source
, 2017 How does a mother supply a key building block of the brain required for neurodevelopment to her fetus in pregnancy? The critical requirement of docosahexaenoic acid (DHA) for fetal brain development, and the poor efficiency of its synthesis in humans, is
Freeman, Dilys J., Meyer, Barbara J.
core
Addiction is Not a Brain Disease (and it Matters) [PDF]
Frontiers in Psychiatry, 2013 The claim that addiction is a brain disease is almost universally accepted among scientists who work on addiction. The claim's attraction rests on two grounds: the fact that addiction seems to be characterized by dysfunction in specific neural pathways and the fact that the claim seems to the compassionate response to people who are suffering.
openaire +4 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
The blood–brain barrier in health and disease: Important unanswered questions
Journal of Experimental Medicine, 2020 The blood vessels of the central nervous system tightly control the movement of ions, molecules, and cells between the blood and tissue. This “blood–brain barrier” is vital for neural homeostasis and protection. This review discusses current knowledge of
C. Profaci +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
DiagnosticsBackground/Objectives: This paper is significant in highlighting the importance of early and precise diagnosis of Parkinson’s Disease (PD) that affects both motor and non-motor functions to achieve better disease control and patient outcomes.
Mehmet Meral +2 more
doaj +1 more source