Results 131 to 140 of about 12,998,191 (376)
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Targeting with nanoparticles for the therapeutic treatment of brain diseases
Journal of Tissue Engineering, 2020 Brain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost.
G. jin +4 more
semanticscholar +1 more source
Brain modularity controls the critical behavior of spontaneous activity
, 2014 The human brain exhibits a complex structure made of scale-free highly connected modules loosely interconnected by weaker links to form a small-world network.
de Arcangelis, Lucilla +2 more
core +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Roles of glial ion transporters in brain diseases
Glia, 2020 Glial ion transporters are important in regulation of ionic homeostasis, cell volume, and cellular signal transduction under physiological conditions of the central nervous system (CNS).
Shanshan Song +3 more
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Formulations of Curcumin Nanoparticles for Brain Diseases
Biomolecules, 2019 Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging ...
M. D. Del Prado-Audelo +7 more
semanticscholar +1 more source
Chloride Homeostasis in Neuronal Disorders: Bridging Measurement to Therapy
LifeNeuronal chloride (Cl−) homeostasis is fundamental for brain function, with disruptions increasingly recognized as pathogenic across neurological disorders.
Daniele Arosio, Carlo Musio
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Molecular mechanisms of ferroptosis and their involvement in brain diseases.
Pharmacology and Therapeutics, 2023 I. Costa +7 more
semanticscholar +1 more source