Results 141 to 150 of about 12,998,191 (376)
24S‐hydroxycholesterol: Cellular effects and variations in brain diseases
Journal of Neurochemistry, 2020 The adult brain exhibits a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme cytochrome P450 46A1 (CYP46A1) or 24‐cholesterol hydroxylase, that
A. Sodero
semanticscholar +1 more source
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To explore the clinical and molecular genetic characteristics of developmental and epileptic encephalopathy type 96 (DEE96) caused by de novo variation in NSF gene.
XU Jia-xuan +4 more
doaj +1 more source
Neurosurgeon's Perspective on Neuroimaging for Headaches
Pediatric Neurology Briefs, 2014 Neurosurgeons at Washington University School of Medicine, St Louis, MO, address the proposed utility and negative impact of guidelines proposed by the American Headache Society (AHS), in conjunction with the Choosing Wisely initiative of the American ...
J Gordon Millichap, John J Millichap
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging
Neural Regeneration Research, 2019 Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease, Parkinson’s disease, stroke and persistent pain.
H. Nakanishi
semanticscholar +1 more source
Guangxi Yike Daxue xuebaoBiomedical research in recent years has revealed a new mechanism by which the brain can effectively remove metabolic waste generated by the neural tissue through the glymphatic system.
CHANG Junlei, FENG Ziying
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Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Pediatric Migraine Prescription Patterns
Pediatric Neurology Briefs, 2014 Investigators at Boston Children's Hospital determined the migraine prescription patterns in 4839 patients, ages 2 to 17 years, treated over a 4-year period.
J Gordon Millichap, John J Millichap
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Ripples and Fast Ripples as Markers for Epileptogenic Zone in TS Complex
Pediatric Neurology Briefs, 2014 Investigators from the Hospital for Sick Children, Toronto, Canada, and Okayama University Hospital, Japan, analyzed the high occurrence rate (OR) of interictal high frequency oscillations (HFOs) at 80-200 Hz (ripples) and >200 Hz (fast ripples, FRs).
J Gordon Millichap, John J Millichap
doaj +1 more source