Results 151 to 160 of about 12,998,191 (376)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Symptoms and Etiologies of Alice in Wonderland Syndrome

Pediatric Neurology Briefs, 2014
Investigators from Children's Hospital of Philadelphia, PA, conducted a retrospective chart review of 48 children (average age at presentation 8.1 yrs, range 5-14 yrs; 73% male) diagnosed with “Alice in Wonderland” syndrome (AWS) or “Alice in Wonderland”-
J Gordon Millichap, John J Millichap
doaj   +1 more source

Neuro-Behçet: a case of intracranial hypertension secondary a inflammatory disease of the brain without trombotic manifestations.

, 2021
Paula Cristina Montina, Carlos Eduardo Lins, Regina Alice Fontes Von Kirchenheim, Jamille Nascimento Carneiro, Victor Junio Pereira Mesquita   +4 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

International Journal of Molecular Sciences, 2018
It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the central nervous system (CNS).
T. Numakawa, Haruki Odaka, N. Adachi
semanticscholar   +1 more source

Symptoms and Etiologies of Pseudotumor Cerebri

Pediatric Neurology Briefs, 2014
Investigators from Ankara Pediatrics, Turkey, evaluate the clinical symptoms and etiology in records of 53 patients (32 female) diagnosed with pseudotumor cerebri (PTC) in a child neurology department between 2005 and 2012.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Phagocytes Containing a Disease-Promoting Toll-Like Receptor/Nod Ligand Are Present in the Brain during Demyelinating Disease in Primates [PDF]

, 2006
L. H. Visser, Marie‐José Melief, Debby van Riel, Marjan van Meurs, Ella A. Sick, Seiichi Inamura, Jeffrey J. Bajramović, Sandra Amor, Rogier Q. Hintzen, Leonie A. Boven, Bert A. ‘t Hart, Jon D. Laman   +11 more
openalex   +1 more source

Identification of molecular network of gut‐brain axis associated with neuroprotective effects of PPARδ‐ligand erucic acid in rotenone‐induced Parkinson's disease model in zebrafish [PDF]

, 2022
İsmail Ünal, Derya Cansız, Mustafa Gani Sürmen, Saime Sürmen, Zehra Sezer, Merih Beler, Ünsal Veli Üstündağ, Elif Güzel, A. Ata Alturfan, Ebru Emekli‐Alturfan   +9 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source