Results 171 to 180 of about 12,470,437 (381)

Emerging Role of PD-1 in the Central Nervous System and Brain Diseases

Neuroscience Bulletin, 2021
Junli Zhao, Alexus Roberts, Zilong Wang, J. Savage, R. Ji   +4 more
semanticscholar   +1 more source

Blood-brain barrier transport machineries and targeted therapy of brain diseases

BioImpacts, 2016
Introduction: Desired clinical outcome of pharmacotherapy of brain diseases largely depends upon the safe drug delivery into the brain parenchyma. However, due to the robust blockade function of the blood-brain barrier (BBB), drug transport into the ...
J. Barar, Mohammad A. Rafi, M. M. Pourseif, Y. Omidi   +3 more
semanticscholar   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Acidemia orgánica (propiónica) en un neonato detectada por espectrometría de masas en tándem

Biomédica: revista del Instituto Nacional de Salud, 2008
La acidemia propiónica es un error innato del metabolismo de herencia autosómica recesiva, causada por la deficiencia de la enzima propionil CoA carboxilasa, que cataliza la conversión de propionil CoA a malonil CoA.
Yolanda Cifuentes, Isabel De la Hoz, Martha Bermúdez, Clara Arteaga   +3 more
doaj   +1 more source

Neuroimaging Studies Illustrate the Commonalities Between Ageing and Brain Diseases

Bioessays, 2018
The lack of specificity in neuroimaging studies of neurological and psychiatric diseases suggests that these different diseases have more in common than is generally considered.
J. Cole
semanticscholar   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Treatment of brain disease in the mucopolysaccharidoses

Molecular Genetics and Metabolism, 2017
The mucopolysaccharidosis (MPS) disorders are a group of lysosomal storage diseases caused by lysosomal enzyme deficits that lead to glycosaminoglycan accumulation, affecting various tissues throughout the body based on the specific enzyme deficiency. These disorders are characterized by their progressive nature and a variety of somatic manifestations ...
Scarpa, Maurizio, Orchard, Paul J., Schulz, Angela, Dickson, Patricia I., Haskins, Mark E., Escolar, Maria L., Giugliani, Roberto   +6 more
openaire   +5 more sources

Advantages and limitations of navigation‐based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard, Simon J. P. Meara, Ehab M. Ibrahim, Carl G. Rowbottom   +3 more
wiley   +1 more source

Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ deposition

Translational Psychiatry
In clinical settings, tumor compression, trauma, surgical injury, and other types of injury can cause hypothalamic damage, resulting in various types of hypothalamic dysfunction.
Guangsen Wu, Yichao Ou, Zhanpeng Feng, Zhiwei Xiong, Kai Li, Mengjie Che, Songtao Qi, Mingfeng Zhou   +7 more
doaj   +1 more source

THE USE OF THE OPHTHALMOSCOPE IN THE DIAGNOSIS OF BRAIN DISEASE. [PDF]

, 1885
W. FRANKLIN COLEMAN
openalex   +1 more source