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Identification of gene biomarkers for brain diseases via multi-network topological semantics extraction and graph convolutional network. [PDF]
BMC GenomicsZhang P +6 more
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The Landscape of Biomimetic Nanovesicles in Brain Diseases
Advances in Materials, 2023Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular diseases, and brain injuries, are caused by various pathophysiological changes, which pose a serious health threat.
Qing You +9 more
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Selenium and selenoproteins in the brain and brain diseases [PDF]
Journal of Neurochemistry, 2003 AbstractOver the past three decades, selenium has been intensively investigated as an antioxidant trace element. It is widely distributed throughout the body, but is particularly well maintained in the brain, even upon prolonged dietary selenium deficiency.
Marla J. Berry, Jun Chen
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Dopamine and the Diseased Brain
CNS & Neurological Disorders - Drug Targets, 2006Dysfunction of central dopaminergic neurotransmission has been implicated in a series of neuropsychiatric disorders, including Tourette's syndrome, schizophrenia, and drug and alcohol dependence. The behavioral and psychopathological manifestations of central dopaminergic dysfunction differ depending on the site of their neurobiological correlate ...
Andreas Heinz, Thorsten Kienast
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Hirschsprung’s disease and the brain
Pediatric Surgery International, 2010A link between factors governing brain development and the development of the ENS is not surprising as both processes are largely controlled by the same or similar neural growth factors which are expressed at more or less in the same spatio-temporal time frame.
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Molecular Neurobiology, 2001
Zinc is one of the most abundant transition metals in the brain. A substantial fraction (10-15%) of brain zinc is located inside presynaptic vesicles of certain glutamatergic terminals in a free or loosely bound state. This vesicle zinc is released with neuronal activity or depolarization, probably serving physiologic functions.
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Zinc is one of the most abundant transition metals in the brain. A substantial fraction (10-15%) of brain zinc is located inside presynaptic vesicles of certain glutamatergic terminals in a free or loosely bound state. This vesicle zinc is released with neuronal activity or depolarization, probably serving physiologic functions.
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Mitochondrial Diseases of the Brain
Free Radical Biology and Medicine, 2013Neurodegenerative disorders are debilitating diseases of the brain, characterized by behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial dysfunction as a central causal factor in the pathogenesis of neurodegenerative disorders including Parkinson's disease, Huntington's disease, Alzheimer's disease, Amyotrophic lateral ...
M. Flint Beal +2 more
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Is obesity a brain disease? [PDF]
Neuroscience & Biobehavioral Reviews, 2013 That the brain is involved in the pathogenesis and perpetuation of obesity is broadly self-intuitive, but traditional evaluation of this relationship has focused on psychological and environment-dependent issues, often referred to as the "it's all in the head" axiom.
Naftali Stern, Yonit Marcus, Gabi Shefer
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Acta Neuropsychiatrica, 2002
Cytokines (e.g. various interleukins and subfamily members, tumor necrosis factors, interferons, chemokines and growth factors) act in the brain as immunoregulators and neuromodulators. Over a decade ago, the integrative article ‘Immunoregulators in the Nervous System’ (Neurosci Biobehav Rev1991; 15: 185–215) provided a comprehensive framework of ...
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Cytokines (e.g. various interleukins and subfamily members, tumor necrosis factors, interferons, chemokines and growth factors) act in the brain as immunoregulators and neuromodulators. Over a decade ago, the integrative article ‘Immunoregulators in the Nervous System’ (Neurosci Biobehav Rev1991; 15: 185–215) provided a comprehensive framework of ...
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Schizophrenia as a Brain Disease
Archives of Neurology, 1993It is now widely accepted that schizophrenia is a brain disease, yet the pathophysiology of this illness is still obscure. In some ways, we are at the same point in understanding the symptoms of this illness that medicine was in understanding the symptoms of heart failure before the circulatory system was discovered.
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