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The Brain in Gaucher's Disease
Archives of Neurology, 1984To the Editor. —In the article by Daniels et al,1enzymatic studies of brain samples from patients with Gaucher's disease are described. The authors either missed or ignored references to our research, which describes studies of brains from patients with Gaucher's disease.
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Evolution and Disease of the Brain
Perspectives in Biology and Medicine, 1958become fossilized, but some evidence can be obtained by making casts of the interior of the cranium. In this way it has been possible for T. Edinger (i) to follow the evolution of the brain of the horse. Most of the reconstruction, however, has been inferred from laborious study of the brains of surviving animals believed, for sufficient reasons, to be
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Veterinary Clinics of North America: Small Animal Practice, 1996
Inherited degenerative diseases of the brain are chronically progressive and often lead to severe debilitation. The cerebellum is particularly susceptible to degenerative processes. For lysosomal storage disorders, the metabolic defect is often known and diagnostic tests are available. For other abiotrophies, the inborn error of metabolism is not known
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Inherited degenerative diseases of the brain are chronically progressive and often lead to severe debilitation. The cerebellum is particularly susceptible to degenerative processes. For lysosomal storage disorders, the metabolic defect is often known and diagnostic tests are available. For other abiotrophies, the inborn error of metabolism is not known
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Biomimetic drug-delivery systems for the management of brain diseases.
Biomaterials Science, 2019Acting as a double-edged sword, the blood-brain barrier (BBB) is essential for maintaining brain homeostasis by restricting the entry of small molecules and most macromolecules from blood. However, it also largely limits the brain delivery of most drugs.
Yaoxing Chen +5 more
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Critical reviews in therapeutic drug carrier systems, 2018
Intranasal drug delivery is emerging as a reliable and promising pathway to deliver a wide range of therapeutic agents including small and large molecules, peptides and proteins, genes to the central nervous system for the treatment of brain diseases ...
Ying Fan +5 more
semanticscholar +1 more source
Intranasal drug delivery is emerging as a reliable and promising pathway to deliver a wide range of therapeutic agents including small and large molecules, peptides and proteins, genes to the central nervous system for the treatment of brain diseases ...
Ying Fan +5 more
semanticscholar +1 more source
Addiction Is a Brain Disease, and It Matters
Focus, 1997Scientific advances over the past 20 years have shown that drug addiction is a chronic, relapsing disease that results from the prolonged effects of drugs on the brain. As with many other brain diseases, addiction has embedded behavioral and social-context aspects that are important parts of the disorder itself.
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The glycine peak in brain diseases
Computerized Medical Imaging and Graphics, 2003Glycine is an excitatory amino acid, a neurotransmitter for the brain. A recent experimental study by a 9.3T laboratory spectrometer identified the peak of pure glycine at 3.52 ppm, and in a clinical case this peak was demonstrated at 3.50 ppm by a 1.5 T clinical scanner.
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