Results 91 to 100 of about 4,168,979 (420)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, Volume 15, Issue 5, Page 726-737, May 2025.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Establishment and validation of a bad outcomes prediction model based on EEG and clinical parameters in prolonged disorder of consciousness

Frontiers in Human Neuroscience
ObjectiveThis study aimed to explore the electroencephalogram (EEG) indicators and clinical factors that may lead to poor prognosis in patients with prolonged disorder of consciousness (pDOC), and establish and verify a clinical predictive model based on
Wanqing Liu, Yongkun Guo, Yongkun Guo, Yongkun Guo, Jingwei Xie, Jingwei Xie, Jingwei Xie, Yanzhi Wu, Dexiao Zhao, Zhe Xing, Xudong Fu, Xudong Fu, Xudong Fu, Shaolong Zhou, Shaolong Zhou, Shaolong Zhou, Hengwei Zhang, Hengwei Zhang, Hengwei Zhang, Xinjun Wang, Xinjun Wang, Xinjun Wang, Xinjun Wang   +22 more
doaj   +1 more source

Concussion classification via deep learning using whole-brain white matter fiber strains [PDF]

, 2017
Developing an accurate and reliable injury predictor is central to the biomechanical studies of traumatic brain injury. State-of-the-art efforts continue to rely on empirical, scalar metrics based on kinematics or model-estimated tissue responses explicitly pre-defined in a specific brain region of interest.
arxiv   +1 more source

Current Medical Research: Summer/Fall 2017 [PDF]

, 2018
This issue of Current Medical Research (CMR) includes studies that provide evidence that use of natural family planning (NFP) can be helpful for subfertile couples wishing to achieve a pregnancy, the effectiveness of a method of NFP during breastfeeding,
Barron, Mary Lee, Fehring, Richard
core   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, Volume 15, Issue 5, Page 793-809, May 2025.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Safety of Intramedullary Autologous Peripheral Nerve Grafts for Post-Rehabilitated Complete Motor Spinal Cord Injuries: A Phase I Study

Acta Medica Iranica, 2013
Many experimental studies have reported behavioral improvement after transplantation of peripheral nerve tissue into the contused spinal cord, even in large animals. The safety of this treatment in human remains unknown.
Nazi Derakhshanrad, Hooshang Saberi, Sajad Shafiee, Mir Saeed Yekaninejad, Mohammad Reza Hadian, Abdolreza Sheikhrezai, Zahid Hussain Khan, Abbas Noruzi Javidan, Amir Hassan Kohan   +8 more
doaj  

Relationship between brain injury criteria and brain strain across different types of head impacts can be different [PDF]

, 2020
Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts. These BIC originated from different types of head impacts (e.g., sports and car crashes) are widely used in risk evaluation. However, the accuracy of using the BIC on brain injury risk estimation across different types of head impacts has not ...
arxiv   +1 more source

2008 Progress Report on Brain Research [PDF]

, 2008
Highlights new research on various disorders, nervous system injuries, neuroethics, neuroimmunology, pain, sense and body function, stem cells and neurogenesis, and thought and memory.
Eve Marder, Mahlon R. DeLong, Michael S. Gazzaniga, Thomas Wichmann   +3 more
core  

Estimating the global incidence of traumatic brain injury.

Journal of Neurosurgery, 2019
OBJECTIVETraumatic brain injury (TBI)-the "silent epidemic"-contributes to worldwide death and disability more than any other traumatic insult. Yet, TBI incidence and distribution across regions and socioeconomic divides remain unknown.
M. Dewan, A. Rattani, Saksham Gupta, R. Baticulon, Ya-Ching Hung, Maria Punchak, A. Agrawal, A. Adeleye, M. Shrime, A. Rubiano, J. Rosenfeld, Kee B. Park   +11 more
semanticscholar   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source