Results 271 to 280 of about 273,197 (337)

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

Optimizing a mouse model of exertional heat stroke to simulate multiorgan and brain injuries. [PDF]

Brain Circ
Peng Y, Fang Z, Li J, Jia Q, Ma H, Li L, Wu Y, Zhang X.   +7 more
europepmc   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source

Palpable signs of skull fractures on physical examination and depressed skull fractures or traumatic brain injuries on CT in children. [PDF]

Eur J Pediatr
Bressan S, Tancredi D, Casper CT, Da Dalt L, Kuppermann N.   +4 more
europepmc   +1 more source

Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver

Advanced Science, EarlyView.
The Fe3O4/Gd@BSA‐pPB nanoprobe leverages biomimetic mineralization and targets hepatic stellate cells (HSCs) through PDGFRβ, offering superior enrichment in fibrotic regions. This targeted delivery overcomes biological barriers, enhancing both the accuracy and sensitivity of MRI imaging at early disease stages.
Zehua Li, Tongwei Zhang, Tongxiang Tao, Yaxuan Liu, Haining Xia, Sajid ur Rehman, Zeyong Guo, Jing Zhang, Ruiguo Chen, Zhan Zhang, Junfeng Wang, Kun Ma   +11 more
wiley   +1 more source

Magnesium-ibogaine therapy in veterans with traumatic brain injuries. [PDF]

Nat Med
Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, Shamma A, Keynan O, Coetzee JP, Batail JM, Phillips A, Bassano NJ, Sahlem GL, Inzunza J, Millar T, Dickinson J, Rolle CE, Keller J, Adamson M, Kratter IH, Williams NR.   +19 more
europepmc   +1 more source

Neural Patterns of Social Pain in the Brain‐Wide Representations Across Social Contexts

Advanced Science, EarlyView.
Empathy arises from both physiological and social pain, yet their shared and context‐specific neural mechanisms remain unclear. Combining fMRI and multivariate pattern analysis, this study decodes overlapping empathy networks and distinct representations for social exclusion versus separation.
Xiaodong Zhang, Peng Qing, Qi Liu, Can Liu, Lei Liu, Xianyang Gan, Kun Fu, Chunmei Lan, Xinqi Zhou, Keith M. Kendrick, Benjamin Becker, Weihua Zhao   +11 more
wiley   +1 more source

Correlation Between Low Platelet-to-Lymphocyte Ratio and High Mortality Rates in Adult Trauma Patients With Moderate-to-Severe Brain Injuries. [PDF]

Emerg Med Int
To KW, Hsu SY, Yu CY, Tsai YC, Lin YC, Hsieh CH.   +5 more
europepmc   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source