Results 111 to 120 of about 4,355,570 (357)

Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model

Critical Care, 2017
Hypoxic ischemic brain injury (HIBI) after cardiac arrest (CA) is a leading cause of mortality and long-term neurologic disability in survivors. The pathophysiology of HIBI encompasses a heterogeneous cascade that culminates in secondary brain injury and
M. Sekhon, P. Ainslie, D. Griesdale
semanticscholar   +1 more source

Brain Energetics, Mitochondria, and Traumatic Brain Injury [PDF]

arXiv, 2019
We review current thinking about, and draw connections between, brain energetics and metabolism, mitochondria and traumatic brain injury. In addition to summarizing current thinking in these disciplines, our goal is to suggest a framework for mechanisms and pathways based on optimal energetic decisions.
arxiv  

Longitudinal abnormalities in white matter extracellular free water volume fraction and neuropsychological functioning in patients with traumatic brain injury [PDF]

arXiv, 2022
Traumatic brain injury is a global public health problem associated with chronic neurological complications and long-term disability. Biomarkers that map onto the underlying brain pathology driving these complications are urgently needed to identify individuals at risk for poor recovery and to inform design of clinical trials of neuroprotective ...
arxiv  

Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: Pathophysiology and potential therapeutic targets

Journal of Neuroscience Research, 2018
Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in young adults and children in the developed world, occurring in over 1.7 million persons and resulting in 50,000 deaths in the United States alone.
Suraj Sulhan, K. Lyon, Lee A. Shapiro, Jason H. Huang   +3 more
semanticscholar   +1 more source

Multi-directional dynamic model for traumatic brain injury detection [PDF]

arXiv, 2018
Traumatic brain injury (TBI) is a complex injury that is hard to predict and diagnose, with many studies focused on associating head kinematics to brain injury risk. Recently, there has been a push towards using computationally expensive finite element (FE) models of the brain to create tissue deformation metrics of brain injury. Here, we developed a 3
arxiv  

Exploring the Production of Extracellular Matrix by Astrocytes in Response to Mimetic Traumatic Brain Injury [PDF]

, 2016
Following injury to the central nervous system, extracellular modulations are apparent at the site of injury, often resulting in a glial scar. Astrocytes are mechanosensitive cells, which can create a neuroinhibitory extracellular environment in response
Walker, Addison
core   +2 more sources

Spatial patterns of progressive brain volume loss after moderate-severe traumatic brain injury

Brain : a journal of neurology, 2018
Using longitudinal neuroimaging, Cole et al. show that traumatic brain injury (TBI) results in progressive loss of brain tissue that continues for years after an injury.
J. Cole, Amy E. Jolly, S. De Simoni, N. Bourke, Maneesh C. Patel, G. Scott, D. Sharp   +6 more
semanticscholar   +1 more source

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

Retrospective analysis of patients with immediate decannulation in severe acquired brain injury (RAPID-SABI)

Journal of Rehabilitation Medicine - Clinical Communications
Objective: To examine an early decannulation protocol in adult severe acquired brain injury (SABI) patients. Design: Retrospective, observational cohort study. Subjects/patients: Tracheotomized SABI patients ≥ 18 years admitted to a neurorehabilitation
Robbert-Jan van Hooff, Mette Lindelof, Emma Ghaziani, Trine Hørmann Thomsen, Christina Kruuse, Christian Gunge Riberholt, Charlotte Rath   +6 more
doaj   +1 more source

Traumatic brain injury in pedestrian–vehicle collisions: Convexity and suitability of some functionals used as injury metrics [PDF]

, 2016
Background and Objective: Abrupt accelerations or decelerations can cause large strain in brain tissues and, consequently, different forms of Traumatic Brain Injury (TBI). In order to predict the effect of the accelerations upon the soft tissues of the
Angelini, Massimo, Arregui Dalmases, Carlos, Crandall, Jeff R., Kerrigan, Jason, Sánchez Molina, David, Velázquez Ameijide, Juan   +5 more
core   +2 more sources