Results 301 to 310 of about 4,355,570 (357)

NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis

Advanced Science, EarlyView.
In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu, Kang Ning, Zhaohao Huang, Binyao Chen, Junjie Chen, Yingying Wen, Jian Bu, Han Hong, Qiaorong Chen, Zhuoqi Zhang, Renbing Jia, Wenru Su   +11 more
wiley   +1 more source

Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors.

, 1993
P Vaughan, Dennis D. Cunningham
openalex   +1 more source

NIR‐II Emissive Persistent Neutral π‐Radical with Rapid Doublet Internal Conversion for Efficient Cancer Photothermal Theranostics

Advanced Science, EarlyView.
Rational design of donor‐acceptor persistent neutral π‐radical develop ultra‐high photostability and thermostability, and simultaneously realize high‐resolution NIR‐II whole‐body angiography, photoacoustic imaging, and photothermal therapy of orthotopic bone tumors with good biosafety.
Qi Zhao, Chunxiao Wu, Yijian Gao, Jing Long, Wei Zhang, Yanan Chen, Yuliang Yang, Yu Luo, Yuxiao Lai, Houyu Zhang, Xiankai Chen, Feng Li, Shengliang Li   +12 more
wiley   +1 more source

Immunolocalization of Heat Shock Protein after Fluid Percussive Brain Injury and Relationship to Breakdown of the Blood-Brain Barrier

, 1993
Hirokazu Tanno, Russ P. Nockels, Lawrence H. Pitts, Linda J. Noble‐Haeusslein   +3 more
openalex   +1 more source

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review

Intensive Care Medicine Experimental
Francesca Motta, Marianna Cerrato, Daria De Giorgio, Alice Salimbeni, Giulia Merigo, Aurora Magliocca, Carlo Perego, Elisa R. Zanier, Giuseppe Ristagno, Francesca Fumagalli   +9 more
doaj   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source