Results 141 to 150 of about 2,529,991 (308)

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury

Molecules, 2018
Neonatal hypoxia–ischemia is one of the main causes of mortality and disability of newborns. To study the mechanisms of neonatal brain cell damage, we used a model of neonatal hypoxia–ischemia in seven-day-old rats, by annealing of the common
Denis N. Silachev, Egor Y. Plotnikov, Irina B. Pevzner, Ljubava D. Zorova, Anastasia V. Balakireva, Mikhail V. Gulyaev, Yury A. Pirogov, Vladimir P. Skulachev, Dmitry B. Zorov   +8 more
doaj   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Amyloid pathology in the brain after ischemia

Folia Neuropathologica, 2019
As the population is aging all over the world, the economic burden of ischemic brain injuries is constantly increasing. Human brain ischemia is one of the leading causes of premature death, significant morbidity and physical and mental disabilities ...
Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław Czuczwar   +3 more
doaj   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

End to End Brain Fiber Orientation Estimation using Deep Learning [PDF]

arXiv, 2018
In this work, we explore the various Brain Neuron tracking techniques, which is one of the most significant applications of Diffusion Tensor Imaging. Tractography provides us with a non-invasive method to analyze underlying tissue micro-structure. Understanding the structure and organization of the tissues facilitates us with a diagnosis method to ...
arxiv  

Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice

Neurobiology of Disease, 2013
Application of isoflurane, a volatile anesthetic, after brain ischemia can reduce ischemic brain injury in rodents (isoflurane postconditioning). This study is designed to determine whether isoflurane postconditioning improves long-term neurological ...
Hong Li, Jinbo Yin, Liaoliao Li, Jiao Deng, Chenzhuo Feng, Zhiyi Zuo   +5 more
doaj  

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Correlation between vegetative dysfunction and cognitive impairment in patients with chronic ischemia of the brain

Бюллетень сибирской медицины, 2008
The purpose of present research is to estimate the correlation between vegetative dysfunction and cognitive impairment in patients with chronic ischemia of the brain. We supervised 112 patients with chronic ischemia of the brain.
T. V. Mokina, D. A. Doschannikov, Ye. A. Аntipenko, A. V. Gustov   +3 more
doaj   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source