Results 141 to 150 of about 358,469 (348)
Advanced Science, EarlyView.FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou +8 more
wiley +1 more source
Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis [PDF]
, 1989 Bo K. Siesjö, Finn Bengtsson
openalex +1 more source
Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation
Advanced Science, EarlyView.LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao +9 more
wiley +1 more source
Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain
, 1964 Oliver H. Lowry +3 more
openalex +1 more source
Cerebral Ischemia and Reperfusion: Prevention of Brain Mitochondrial Injury by Lidoflazine [PDF]
, 1987 Robert E. Rosenthal +4 more
openalex +1 more source
Advanced Science, EarlyView.Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley +1 more source
Pial Arterial Responses in the Cat Brain Following Prolonged Ischemia
, 1978 S. Takagi +3 more
openalex +2 more sources
Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop
Advanced Science, EarlyView.The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu +22 more
wiley +1 more source
An alternative view of heparin anticoagulation in acute focal brain ischemia.
, 1989 Michael D. Hill
openalex +1 more source
Advanced Science, EarlyView.This research introduces a novel approach to enhance neuroregeneration following Traumatic Brain Injury (TBI). Extracellular Vesicles (EVs) are isolated from human neural progenitor cells under hypoxic conditions, leading to enhanced expression of neurogenic and angiogenic factors.
Joshua B. Stein +9 more
wiley +1 more source