Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Silencing of NEFL inhibits the inflammatory response and functional recovery following spinal cord injury. Abstract Background Neurofilament light chain (NEFL) has been identified as a biomarker for spinal cord injury (SCI), but its effect and underlying mechanism in SCI remain unclear.
Hui Zhang +4 more
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Cerebral Ischemia and Reperfusion: Prevention of Brain Mitochondrial Injury by Lidoflazine [PDF]
, 1987 Robert E. Rosenthal +4 more
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Dynamic Pathophysiological Insight into the Brain by NIR‐II Imaging
Advanced Science, EarlyView.The functional integration of benefits from small semiconducting dyes and biocompatible serum proteins ushered in a new frontier of deep wide‐field in vivo imaging technique, affording valuable pathophysiological insight into the functioning of neurovascular unit in space and time.
Si Chen +9 more
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The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Background Ischemic stroke (IS), a multifactorial and polygenic disease, is the most common cause of death. This study aimed to determine the roles of MMP8/MMP10 polymorphisms in IS susceptibility in the Chinese Han population. Methods MMP8 rs1940475 and rs3765620, and MMP10 rs17860949 from 700 IS patients and 700 controls were genotyped by ...
Yong Zhao +11 more
wiley +1 more source
Effect of Adenosine Receptor Agonist and Ascorbic Acid on Ultrastructure of Hippocampal CA1 Neurons after Ischemia-Reperfusion Injury [PDF]
, 2017 Background: In brain ischemia, blood and oxygen supply decrease and after reperfusion, free radicals and reactive oxygen species (ROS) cause severe damage.
Alizadeh, Akram. +3 more
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Longitudinal, Multimodal Tracking Reveals Lasting Neurovascular Impact of Individual Microinfarcts
Advanced Science, EarlyView.Jin et al. investigate the neurovascular impact of microinfarcts, revealing transient neural suppression with minimal cell death and recovery linked to vascular remodeling. Fast‐spiking interneurons exhibit reduced excitability, whereas regular‐spiking neurons showed increased bursting activity. Disruptions in low‐gamma phase locking suggest persistent
Yifu Jin +9 more
wiley +1 more source
Brain and Behavior, Volume 12, Issue 12, December 2022., 2022 Abstract Objective This study sought to evaluate the feasibility of multifunctional gastrodin (GAS)‐containing nano‐drug carrier system against cerebral ischemia–reperfusion injury (CIRI). Methods The drug‐loaded nanocomposite (Au‐G5.NHAc‐PS/GAS) with certain encapsulation efficiency (EE) was prepared by physical adsorption method using different ...
Wenqiang Huang +8 more
wiley +1 more source
Inhibition of central angiotensin-converting enzyme with enalapril protects the brain from ischemia/reperfusion injury in normotensive rat [PDF]
Background and the Purpose of the study: Central Angiotensin Converting Enzyme (ACE) has an important role on cerebral microcirculation and metabolism.
دهقان, غلامعباس +1 more
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Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis [PDF]
, 1989 Bo K. Siesjö, Finn Bengtsson
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Advanced Science, EarlyView.LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao +7 more
wiley +1 more source