Results 191 to 200 of about 2,710,974 (373)

Gompertz Law‐Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks

Advanced Science, EarlyView.
The Gompertz law‐based biological age metric (GOLD BioAge) introduces interpretable convenient and interpretable calculations to capture mortality, disease, and frailty risks. Its applications to proteomics and metabolomics (ProtAge and MetAge) demonstrate clinical potential to enhance aging evaluation and prevent age‐related diseases.
Meng Hao, Hui Zhang, Jingyi Wu, Yaqi Huang, Xiangnan Li, Meijia Wang, Shuming Wang, Jiaofeng Wang, Jie Chen, Zhi jun Bao, Li Jin, Xiaofeng Wang, Zixin Hu, Shuai Jiang, Yi Li   +14 more
wiley   +1 more source

Exogenous oxygen is required for prostanoid induction under brain ischemia as evidence for a novel regulatory mechanism. [PDF]

J Lipid Res, 2023
Seeger DR, Schofield B, Besch D, Golovko SA, Kotha P, Parmer M, Solaymani-Mohammadi S, Golovko MY.   +7 more
europepmc   +1 more source

Recirculation in the Rat Brain following Incomplete Ischemia

, 1983
Erik Kågström, Maj‐Lis Smith, Bo K. Siesjö   +2 more
openalex   +1 more source

Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo. [PDF]

, 1990
I.A. Silver, Maria Erecińska
openalex   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Hypoxia-Ischemia Stimulates Hippocampal Glutamate Efflux in Perinatal Rat Brain: An In Vivo Microdialysis Study [PDF]

, 1991
Faye S. Silverstein, Bina Naik, Jennifer Simpson   +2 more
openalex   +1 more source

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia. [PDF]

Biomolecules, 2022
Zalewska T, Pawelec P, Ziabska K, Ziemka-Nalecz M.   +3 more
europepmc   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

The Significance of Brain Temperature in Focal Cerebral Ischemia: Histopathological Consequences of Middle Cerebral Artery Occlusion in the Rat [PDF]

, 1992
Eiharu Morikawa, Myron D. Ginsberg, W. Dalton Dietrich, Robert Duncan, Susan Kraydieh, Mordecai Y.‐T. Globus, Raul Busto   +6 more
openalex   +1 more source