Results 191 to 200 of about 2,811,049 (348)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Perampanel Regulates Neuroinflammation and Ferroptosis via Activating FSP1 Following Brain Ischemia. [PDF]

J Inflamm Res
Lv JM, Pan YJ, Wang X, Zhang MM, Li W, Liu J, Wang T.   +6 more
europepmc   +1 more source

Prevalence and risk factors of ischemic monocular vision loss and concurrent brain ischemia. [PDF]

Eur Stroke J, 2023
Smith CE, Kukolja J.
europepmc   +1 more source

Unfolded protein response in brain ischemia: A timely update

Journal of Cerebral Blood Flow and Metabolism, 2016
Wei Yang, W. Paschen
semanticscholar   +1 more source

Role of rno-miR-124-3p in regulating MCT1 expression in rat brain after permanent focal cerebral ischemia

, 2019
Shiye Xu, Xuli Jiang, Qian Liu, Jin Xu, Juan Huang, Shengwei Gan, Weitian Lu, Fei Zhuo, Mei Yang, Shanquan Sun   +9 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Therapeutic Potential of Natural Compounds for Brain Ischemia-Reperfusion Injury. [PDF]

Biology (Basel)
Yoo KY, Won MH, Ahn JH, Park JH.
europepmc   +1 more source

Sexual Dimorphism in Neurodegenerative Diseases and in Brain Ischemia. [PDF]

Biomolecules, 2022
Zalewska T, Pawelec P, Ziabska K, Ziemka-Nalecz M.   +3 more
europepmc   +1 more source

Role of endothelium dysfunction in starting immunopathologic response in chronic brain ischemia

, 2008
Г. И. Шумахер, Ye. N. Vorobiyova, Ye. V. Nechounayeva, М. А. Хорева, R. I. Vorobiyov, О. Г. Симонова, И А Батанина   +6 more
openalex   +2 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source