Results 231 to 240 of about 2,710,974 (373)

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang   +7 more
wiley   +1 more source

Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia. [PDF]

open access: yesProc Natl Acad Sci U S A
Zucha D   +6 more
europepmc   +1 more source

PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia. [PDF]

open access: yesBiomedicines, 2023
Luo D   +7 more
europepmc   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin   +10 more
wiley   +1 more source

Silent brain ischemia within the TAXINOMISIS framework: association with clinical and advanced ultrasound metrics. [PDF]

open access: yesFront Neurol
Kigka V   +22 more
europepmc   +1 more source

Immunohistochemical Observations of Changes of Neurons Containing Endogenous Vasodilators Produced by Transient Cerebral Ischemia in the Amygdaloid Complex of the Rat Brain

open access: bronze, 1993
Ken Sasaki   +7 more
openalex   +2 more sources

Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke

open access: yesAdvanced Science, EarlyView.
Delayed transplantation of human iPSC‐derived neural progenitor cells (NPCs) enhances graft survival, proliferation, and axonal sprouting after stroke. Using bioluminescence imaging and histology in a mouse model of stroke, it is shown that NPC delivery at 7 days post‐stroke is more effective than acute transplantation, highlighting the importance of ...
Rebecca Z Weber   +6 more
wiley   +1 more source

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