Results 261 to 270 of about 2,710,974 (373)

Effects of adrenaline and vasopressin on cerebral microcirculation at baseline and during global brain ischemia and reperfusion in rabbits. [PDF]

BMC Anesthesiol, 2022
Kondo D, Asano N, Ishiyama T, Shintani N, Matsukawa T.   +4 more
europepmc   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

A mechanistic systems biology model of brain microvascular endothelial cell signaling reveals dynamic pathway-based therapeutic targets for brain ischemia. [PDF]

Redox Biol
Li G, Ma Y, Zhang S, Lin W, Yao X, Zhou Y, Zhao Y, Rao Q, Qu Y, Gao Y, Chen L, Zhang Y, Han F, Sun M, Zhao C.   +14 more
europepmc   +1 more source

Longitudinal association of premature atrial contractions with atrial fibrillation and brain ischemia in people with type 2 diabetes: The Hoorn Diabetes Care System cohort. [PDF]

Am Heart J Plus, 2023
Harms PP, Himmelreich JCL, Blom MT, Beulens JWJ, Nijpels G, Elders P, Lucassen WAM.   +6 more
europepmc   +1 more source

Distributions of Heat Shock Protein-70 mRNAs and Heat Shock Cognate Protein-70 mRNAs after Transient Global Ischemia in Gerbil Brain

, 1992
J. Kawagoe, K. Abe, Shingo Sato, I. Nagano, S. Nakamura, Kyuya Kogure   +5 more
openalex   +1 more source

Bioprinted Organoids: An Innovative Engine in Biomedicine

Advanced Science, EarlyView.
Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li, Kai Li, Cheng Zhang, Yingying Zhao, Yiyuan Guo, Jia He, Shiyuan Chang, Xinyi Fang, Kaizheng Liu, Pingping Zhu, Zhenzhen Chen, Changshun Ruan   +11 more
wiley   +1 more source

Modulating the RPS27A/PSMD12/NF-κB pathway to control immune response in mouse brain ischemia-reperfusion injury. [PDF]

Mol Med
Li X, Qiao M, Zhou Y, Peng Y, Wen G, Xie C, Zhang Y.   +6 more
europepmc   +1 more source

Neural cortical organoids from self-assembling human iPSC as a model to investigate neurotoxicity in brain ischemia. [PDF]

J Cereb Blood Flow Metab, 2023
De Paola M, Pischiutta F, Comolli D, Mariani A, Kelk J, Lisi I, Cerovic M, Fumagalli S, Forloni G, Zanier ER.   +9 more
europepmc   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Temporal expression profiles of microRNAs associated with acute phase of brain ischemia in gerbil hippocampus. [PDF]

Heliyon
Hamada Y, Takata T, Iwama H, Kawakita R, Nonaka W, Deguchi K, Kobara H, Morishita A, Miyamoto O, Nakamura T, Itano T, Masaki T.   +11 more
europepmc   +1 more source