Results 81 to 90 of about 128 (125)
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, EarlyView.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
Developmental Medicine &Child Neurology, EarlyView.This study evaluated the Total Abnormality Score (TAS) from cMRI at term‐equivalent age as a predictor of cerebral palsy (CP) in 137 infants born preterm or with low birthweight. Infants who developed CP had significantly higher TAS values (median 11 vs 2), with a TAS cut‐off of 9.5 demonstrating high sensitivity (88.9%) and specificity (91.4%) for CP ...
Anne‐Kathrin Dathe +6 more
wiley +1 more source
Clinical and genetic characterization of intellectual disability
Developmental Medicine &Child Neurology, EarlyView.This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara +14 more
wiley +1 more source
The cerebral palsy directed acyclic graph: A structural causal model of aetiology
Developmental Medicine &Child Neurology, EarlyView.The first international cerebral palsy directed acyclic graph (CP‐DAG) maps over 100 nodes and 370 links across biological, clinical, and social domains, offering a unified causal framework to guide research and identify knowledge gaps. Abstract Aim To describe the development of the initial version of the cerebral palsy (CP) directed acyclic graph ...
Shona Goldsmith +9 more
wiley +1 more source
Causal subgroups and declining rates of cerebral palsy in Victoria, Australia
Developmental Medicine &Child Neurology, EarlyView.In this population‐based study, the main contributors to declining rates of cerebral palsy in Victoria, Australia, were causal subgroups involving presumed perinatal brain insults in neonates born preterm and at term requiring higher nursery care.
Susan M. Reid +4 more
wiley +1 more source
MRI, Child Opportunity Index, and 4‐year cognitive outcome after neonatal encephalopathy
Developmental Medicine &Child Neurology, EarlyView.Abstract Aim To evaluate the association of neonatal magnetic resonance imaging (MRI) and Child Opportunity Index (COI) with 4‐year cognitive outcomes after neonatal encephalopathy. Method This was a cross‐sectional analysis of 4‐year outcomes (interquartile range [IQR] = 48–52 months) in a single‐center prospective cohort of term neonatal ...
Ashley M. Bach +7 more
wiley +1 more source
Upper‐limb movement in infants at risk for unilateral spastic cerebral palsy: A scoping review
Developmental Medicine &Child Neurology, EarlyView.This scoping review mapped current evidence on early upper limb movements in infants aged 0–12 months indicative of developing unilateral spastic cerebral palsy (USCP). Clinical signs of USCP become more apparent with increasing age. However, data also suggest that early signs in upper limb movements might be present from the first weeks of life but ...
Cornelia H. Verhage +5 more
wiley +1 more source
Inborn errors of immunity in children with neuroinflammation
Developmental Medicine &Child Neurology, EarlyView.Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu +5 more
wiley +1 more source
Stimulating proteasomal degradation in human proteinopathies
The FEBS Journal, EarlyView.The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch +2 more
wiley +1 more source
Gerodontology, EarlyView.ABSTRACT Background Periodontitis is a prevalent chronic inflammatory condition that frequently co‐occurs with systemic chronic diseases. Although older adults experience a high burden of both periodontitis and chronic conditions, the extent to which age‐specific evidence has been synthesised remains unclear.
Manisha Tamrakar +4 more
wiley +1 more source